Title:
PHARMACEUTICAL COMPOSITION COMPRISING POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2016/148201
Kind Code:
A1
Abstract:
Discovered is a pharmaceutical composition that sustainedly releases a drug over a long time period after being administered into a body. Provided is the pharmaceutical composition comprising the drug and a polypeptide represented by Ac-(Arg-Ala-Asp-A1a)4-NH2, the pharmaceutical composition further comprising an organic solvent selected from the group consisting of polyethylene glycol, dimethyl sulfoxide, glycofurol, and N-methyl pyrrolidone.
Inventors:
MIYAZAKI TATSUYA (JP)
MASAKI KENJI (JP)
OKABE KOMEI (JP)
YAMADA KAZUHITO (JP)
MASAKI KENJI (JP)
OKABE KOMEI (JP)
YAMADA KAZUHITO (JP)
Application Number:
PCT/JP2016/058359
Publication Date:
September 22, 2016
Filing Date:
March 16, 2016
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K45/00; A61K31/444; A61K47/10; A61K47/20; A61K47/22; A61K47/42; A61P27/02
Domestic Patent References:
| WO2013126017A1 | 2013-08-29 |
Foreign References:
| JP2006096739A | 2006-04-13 | |||
| JP2015083565A | 2015-04-30 |
Other References:
BRIUGLIA, MARIA-LUCIA ET AL.: "Sustained and controlled release of lipophilic drugs from a self-assembling amphiphilic peptide hydrogel", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 474, no. 1, 20 August 2014 (2014-08-20), pages 103 - 111, XP029064369
LIU, JINGPING ET AL.: "Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 6, 2011, pages 2143 - 2153, XP055312077
LI, FENG ET AL.: "Fluorescence Studies on a Designed Self-Assembling Peptide of RAD16-II as a Potential Carrier for Hydrophobic Drug", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 9, no. 2, 2009, pages 1611 - 1614, XP009501843
See also references of EP 3272360A4
LIU, JINGPING ET AL.: "Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 6, 2011, pages 2143 - 2153, XP055312077
LI, FENG ET AL.: "Fluorescence Studies on a Designed Self-Assembling Peptide of RAD16-II as a Potential Carrier for Hydrophobic Drug", JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, vol. 9, no. 2, 2009, pages 1611 - 1614, XP009501843
See also references of EP 3272360A4
Attorney, Agent or Firm:
NISHIJIMA Takaki et al. (JP)
Takayoshi Nishijima (JP)
Takayoshi Nishijima (JP)
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