Title:
PHARMACEUTICAL COMPOSITION CONTAINING DORZAGLIATIN AND GLUCAGON-LIKE PEPTIDE-1 ANALOG
Document Type and Number:
WIPO Patent Application WO/2022/144021
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition, comprising (a) Dorzagliatin, or an isotopic marker, enantiomer, diastereoisomer, pharmaceutically acceptable salt, hydrate, solvate, or crystalline form thereof; and (b) a GLP-1 analog, or a pharmaceutically acceptable salt thereof. The present invention further relates to a kit and pharmaceutical composition containing (a) and (b), and uses thereof, etc.
Inventors:
CHEN LI (CN)
TANG FUXING (CN)
SONG HAOLIANG (CN)
SHAN YONGQIANG (CN)
FU XIN (CN)
TANG FUXING (CN)
SONG HAOLIANG (CN)
SHAN YONGQIANG (CN)
FU XIN (CN)
Application Number:
PCT/CN2022/070063
Publication Date:
July 07, 2022
Filing Date:
January 04, 2022
Export Citation:
Assignee:
HUA MEDICINE SHANGHAI LTD (CN)
International Classes:
A61K45/06; A61K31/4155; A61P3/00; A61P3/04; A61P3/10; A61P5/50; A61P9/10
Foreign References:
| CN102007118A | 2011-04-06 |
Other References:
YU GANG: "Research Progress in Glucokinase Activators", PROGRESS IN PHARMACEUTICAL SCIENCES, CHINA PHARMACEUTICAL UNIVERSITY, CN, vol. 40, no. 3, 25 March 2016 (2016-03-25), CN , pages 168 - 177, XP055755761, ISSN: 1001-5094
DHANESHA NIRAV; JOHARAPURKAR AMIT; SHAH GAURANG; KSHIRSAGAR SAMADHAN; PATEL VISHAL; PATEL KARTIK; BAHEKAR RAJESH; JAIN MUKUL: "Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 714, no. 1, 25 June 2013 (2013-06-25), NL , pages 188 - 192, XP028701092, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2013.06.015
HU, YU-XI; CHEN, YONG-SHOU; REN, YI-XIN; CAO, SHUANG: "Novel drug for type 2 diabetes-glucokinase agonist HMS5552", CLINICAL MEDICATION JOURNAL, vol. 18, no. 6, 30 June 2020 (2020-06-30), pages 1 - 5, XP009537976, ISSN: 1672-3384, DOI: 10.3969/j.issn.1672-3384.2020.06.001
WANG PING, LIU HUILI, CHEN LI, DUAN YINGLI, CHEN QUNLI, XI SHOUMIN: "Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus", JOURNAL OF DIABETES RESEARCH, HINDAWI PUB. CORP., vol. 2017, 1 January 2017 (2017-01-01), pages 1 - 9, XP055948135, ISSN: 2314-6745, DOI: 10.1155/2017/5812607
KIM MI-KYUNG, CHO JIN-HWAN, LEE JAE-JIN, CHEONG YE-HWANG, SON MOON-HO, LEE KONG-JOO: "Differential Protective Effects of Exenatide, an Agonist of GLP-1 Receptor and Piragliatin, a Glucokinase Activator in Beta Cell Response to Streptozotocin-Induced and Endoplasmic Reticulum Stresses", PLOS ONE, vol. 8, no. 9, 19 September 2013 (2013-09-19), pages e73340, XP055948134, DOI: 10.1371/journal.pone.0073340
DHANESHA NIRAV; JOHARAPURKAR AMIT; SHAH GAURANG; KSHIRSAGAR SAMADHAN; PATEL VISHAL; PATEL KARTIK; BAHEKAR RAJESH; JAIN MUKUL: "Treatment with exendin-4 improves the antidiabetic efficacy and reverses hepatic steatosis in glucokinase activator treated db/db mice", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 714, no. 1, 25 June 2013 (2013-06-25), NL , pages 188 - 192, XP028701092, ISSN: 0014-2999, DOI: 10.1016/j.ejphar.2013.06.015
HU, YU-XI; CHEN, YONG-SHOU; REN, YI-XIN; CAO, SHUANG: "Novel drug for type 2 diabetes-glucokinase agonist HMS5552", CLINICAL MEDICATION JOURNAL, vol. 18, no. 6, 30 June 2020 (2020-06-30), pages 1 - 5, XP009537976, ISSN: 1672-3384, DOI: 10.3969/j.issn.1672-3384.2020.06.001
WANG PING, LIU HUILI, CHEN LI, DUAN YINGLI, CHEN QUNLI, XI SHOUMIN: "Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus", JOURNAL OF DIABETES RESEARCH, HINDAWI PUB. CORP., vol. 2017, 1 January 2017 (2017-01-01), pages 1 - 9, XP055948135, ISSN: 2314-6745, DOI: 10.1155/2017/5812607
KIM MI-KYUNG, CHO JIN-HWAN, LEE JAE-JIN, CHEONG YE-HWANG, SON MOON-HO, LEE KONG-JOO: "Differential Protective Effects of Exenatide, an Agonist of GLP-1 Receptor and Piragliatin, a Glucokinase Activator in Beta Cell Response to Streptozotocin-Induced and Endoplasmic Reticulum Stresses", PLOS ONE, vol. 8, no. 9, 19 September 2013 (2013-09-19), pages e73340, XP055948134, DOI: 10.1371/journal.pone.0073340
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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