PHARMACEUTICAL COMPOSITION CONTAINING CBFβ-EXPRESSING VASCULAR SMOOTH MUSCLE CELLS OR CULTURE FLUID THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF AGE-RELATED DISEASES - KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND

Title:

PHARMACEUTICAL COMPOSITION CONTAINING CBFβ-EXPRESSING VASCULAR SMOOTH MUSCLE CELLS OR CULTURE FLUID THEREOF AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF AGE-RELATED DISEASES

Document Type and Number:

WIPO Patent Application WO/2024/063484

Kind Code:

A1

Abstract:

The present invention relates to a pharmaceutical composition containing Cbfβ (Core-binding factor subunit beta) expressing vascular smooth muscle cells or a culture fluid thereof as an active ingredient for the prevention or treatment of age-related diseases. It has been found that inhibition of Cbfβ expression in vascular smooth muscle cells promotes vascular calcification and osteoclast differentiation and that the culture fluid of Cbfβ-expressing vascular smooth muscle cells inhibits osteoclast differentiation. Thus, the composition can be advantageously utilized as a pharmaceutical composition for the prevention, treatment, alleviation, or diagnosis of age-related diseases.

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Inventors:

CHOI JE-YONG (KR)
CHE XIANGGUO (KR)
JIN XIAN (KR)

Application Number:

PCT/KR2023/014083

Publication Date:

March 28, 2024

Filing Date:

September 18, 2023

Export Citation:

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Assignee:

KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)

International Classes:

C12Q1/6883; C12N5/071; C12N5/078; C12N15/85

Domestic Patent References:

WO2021207655A1

2021-10-14

Foreign References:

KR102249135B1	2021-05-07
KR20210062959A	2021-06-01
KR20220127749A	2022-09-20
US20180282700A1	2018-10-04

Other References:

CHE XIANGGUO, JIN XIAN, PARK NA RAE, KIM HEE-JUNE, KYUNG HEE-SOO, KIM HYUN-JU, LIAN JANE B., STEIN JANET L., STEIN GARY S., CHOI J: "Cbfβ Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-β Signaling", CELLS, vol. 12, no. 7, 1 April 2023 (2023-04-01), pages 1064, XP093149311, ISSN: 2073-4409, DOI: 10.3390/cells12071064

Attorney, Agent or Firm:

TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)

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