Title:
PHARMACEUTICAL COMPOSITION CONTAINING EXTRACELLULAR DOMAIN OF ALPHA SUBUNIT OF IGE FC RECEPTOR
Document Type and Number:
WIPO Patent Application WO/2019/135666
Kind Code:
A1
Abstract:
The present invention provides a use of a polypeptide protein dimer having two monomers containing an extracellular domain of an alpha subunit of an IgE Fc receptor (FcεRIa-ECD). A fusion protein according to the present invention has an advantage in that the fusion protein has a binding ability superior to that of conventional therapeutic agents containing an anti-IgE antibody and there are few other side effects due to a lack of ADCC and CDC functionality. Therefore, the fusion protein according to the present invention can be applied to medicine for therapeutic or prophylactic use against allergic diseases mediated by IgE.
Inventors:
SUNG YOUNG CHUL (KR)
YANG ZUNGYOON (KR)
YANG ZUNGYOON (KR)
Application Number:
PCT/KR2019/000270
Publication Date:
July 11, 2019
Filing Date:
January 08, 2019
Export Citation:
Assignee:
PROGEN CO LTD (KR)
International Classes:
A61K38/16; A23L33/18; A61P37/08
Domestic Patent References:
| WO2008028068A2 | 2008-03-06 |
Foreign References:
| KR20170120579A | 2017-10-31 | |||
| US20080300188A1 | 2008-12-04 |
Other References:
TAKAHASHI, K. ET AL.: "The High Affinity IgE Receptor (FcepsilonRI) as a Target for Anti-allergic Agents", ALIERGOLOGY INTERNATIONAL, vol. 54, no. 1, 2005, pages 1 - 5, XP009102529, doi:10.2332/allergolint.54.1
DATABASE Protein 10 October 2012 (2012-10-10), "Chain A, High Affinity Immunoglobulin Epsilon Receptor Alpha- Subunit", XP055620253, retrieved from NCBI Database accession no. 1J89A
DATABASE Protein 19 January 2015 (2015-01-19), "Anti-human CD 40 12E12 antibody HIV antigen fusion protein [synthetic construct", XP055620258, retrieved from NCBI Database accession no. AJD85779.1
DATABASE Protein 1 August 2016 (2016-08-01), "immunoglobulin delta-chain, partial [Homo sapiens]", XP055620260, retrieved from NCBI Database accession no. AAA52771.1
DATABASE Protein 1 August 2016 (2016-08-01), "immunoglobulin delta-chain, partial [Homo sapiens]", XP055620261, retrieved from NCBI Database accession no. AAA52770.1
DATABASE Protein 10 October 2012 (2012-10-10), "Chain A, High Affinity Immunoglobulin Epsilon Receptor Alpha- Subunit", XP055620253, retrieved from NCBI Database accession no. 1J89A
DATABASE Protein 19 January 2015 (2015-01-19), "Anti-human CD 40 12E12 antibody HIV antigen fusion protein [synthetic construct", XP055620258, retrieved from NCBI Database accession no. AJD85779.1
DATABASE Protein 1 August 2016 (2016-08-01), "immunoglobulin delta-chain, partial [Homo sapiens]", XP055620260, retrieved from NCBI Database accession no. AAA52771.1
DATABASE Protein 1 August 2016 (2016-08-01), "immunoglobulin delta-chain, partial [Homo sapiens]", XP055620261, retrieved from NCBI Database accession no. AAA52770.1
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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