Title:
PHARMACEUTICAL COMPOSITION CONTAINING HYALURONIC ACID NANOPARTICLES FOR PREVENTING OR TREATING INFLAMMATORY DISEASE AND METABOLIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/070711
Kind Code:
A2
Abstract:
The present invention relates to a pharmaceutical composition containing hyaluronic acid nanoparticles for preventing or treating an inflammatory disease and a metabolic disease and, more specifically, to a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease, the composition containing hyaluronic acid nanoparticles formed by allowing hyaluronic acid and 5β-cholanic acid or polycaprolactone to be bound to a hydrophobic moiety of the hyaluronic acid through self-assembly in an aqueous solution state. The pharmaceutical composition containing hyaluronic acid nanoparticles for preventing or treating an inflammatory disease or a metabolic disease according to the present invention has effects of reducing the body weight, decreasing the food intake, reducing the blood glucose as a result of glucose tolerance test (GTT), lowering the insulin resistance, reducing inflammation-inducing factors (NF-κB, IL-1β, CD44, TNF-α, NLRP3 inflammasome, and the like), and reducing the tissue infiltration of macrophages, alleviating arthritic symptoms, and reducing the prevalence rate thereof, and thus the composition of the present invention can be favorably used as a pharmaceutical composition for preventing or treating an inflammatory disease and a metabolic disease.
Inventors:
KIM WOOK (KR)
HAN HWA SEUNG (KR)
PARK JAE HYUNG (KR)
RHO JUN GI (KR)
YOON JUHWAN (KR)
HAN HWA SEUNG (KR)
PARK JAE HYUNG (KR)
RHO JUN GI (KR)
YOON JUHWAN (KR)
Application Number:
PCT/KR2017/010824
Publication Date:
April 19, 2018
Filing Date:
September 28, 2017
Export Citation:
Assignee:
UNIV AJOU IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K9/51; A23L33/00; A61K31/728; A61K47/34
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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