Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION CONTAINING ICG-001 FOR PREVENTING OR TREATING FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2018/079966
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition containing ICG-001 for preventing or treating fibrosis, more specifically to a pharmaceutical composition, containing ICG-001 which powerfully inhibits collagen generation, for preventing or treating dermatofibroma (hypertrophic scarring, keloid, scleroderma, and the like) and systemic fibrotic diseases (pulmonary fibrosis, liver cirrhosis, atrial fibrosis, glial scarring, Crohn's disease, myelofibrosis, systemic fibrosis, and the like). The pharmaceutical composition containing ICG-001 for preventing or treating fibrosis according to the present invention has been confirmed to be a strong inhibitor of collagen synthesis in fibroblasts, and accordingly can be effectively utilized as a therapeutic agent for fibrosis which occur from accumulation of connective tissue, such as collagen and glycosaminoglycans, due to proliferation of fibroblasts.

Inventors:
YOON TAE-JIN (KR)
KIM KYUNG-IL (KR)
Application Number:
PCT/KR2017/005739
Publication Date:
May 03, 2018
Filing Date:
June 01, 2017
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
A61K31/519; A23L33/10
Foreign References:
KR20080003350A2008-01-07
US20160263131A12016-09-15
Other References:
HENDERSON, JR.: "Inhibition of Wnt/beta-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis", PNAS, 2010, pages 14309 - 14314, XP055183820, DOI: doi:10.1073/pnas.1001520107
ENZO, M. V.: "The Wnt/beta-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target", MOLECULAR AND ,.., CELLULAR THERAPIES, vol. 1, 2015, pages 1 - 13, XP021218822
HAO, S.: "Targeted inhibition of beta-catenin/CBP signaling ameliorates renal interstitial fibrosis", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 22, no. 9, 2011, pages 1642 - 1653, XP055606023
KIM, K. I.: "Inhibition of collagen production by ICG-001, a small molecule inhibitor for Wnt/beta-catenin signaling, in skin fibroblasts", JOURNAL OF DERMATOLOGICAL SCIENCE, 6 January 2017 (2017-01-06), pages 71 - 78, XP029943504
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
Download PDF: