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Title:
PHARMACEUTICAL COMPOSITION CONTAINING INSULIN-LIKE GROWTH FACTOR-2 AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/099363
Kind Code:
A1
Abstract:
Provided is the use of an insulin-like growth factor-2 for preparing a pharmaceutical composition, wherein the pharmaceutical composition is used for (i) promoting the expression of the macrophage PD-L1, and/or (ii) inhibiting the expression of the macrophage IL-1β. Also provided is a pharmaceutical composition containing the insulin-like growth factor-2 as an active ingredient.

Inventors:
SHI YUFANG (CN)
WANG YING (CN)
DU LIMING (CN)
LIN LIANGYU (CN)
Application Number:
PCT/CN2017/113341
Publication Date:
June 07, 2018
Filing Date:
November 28, 2017
Export Citation:
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Assignee:
SHANGAHI INST FOR BIOLOGICAL SCIENCES CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
A61K35/15; A61K38/30; A61K45/06; A61P1/00; A61P1/16; A61P3/10; A61P5/50; A61P19/02; A61P25/28; A61P37/02; A61P37/04; C12N5/0786
Foreign References:
CN1469752A2004-01-21
CN105007942A2015-10-28
Other References:
UCHIMURA, T. ET AL.: "Insulin-like growth factor II (IGF-II) Inhibits IL -1 0 -Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 116, no. 12, May 2015 (2015-05-01), pages 2858 - 2869, XP055490477
CHEN, J. ET AL.: "Regulation of PD-LI: a novel role of pro-survival signalling in cancer", ANNALS OF ONCOLOGY, vol. 27, no. 3, 17 December 2015 (2015-12-17), pages 409 - 416, XP055362125
HAMAMURA, K. ET AL.: "IGF2-driven PI3 kinase and TGF 0 signaling pathways in chondrogenesis", CELL BIOLOGY INTERNATIONAL, vol. 32, no. 10, 31 December 2008 (2008-12-31), pages 1238 - 1246, XP025479905
YANG, G. ET AL.: "Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model.", J. ALLERGY. CLIN. IMMUNOL, vol. 133, no. 6, 1 April 2014 (2014-04-01), pages 1702 - 1708, XP055490485
YANG, LIJUAN ET AL.: "Progress in relationship between Thl7 and Th1/Treg cell", IMMUNOLOGICAL JOURNAL, vol. 26, no. 4, 30 April 2010 (2010-04-30), pages 353 - 355, XP009515533, DOI: 10.13431/j.cnki.immunol.j.20100083
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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