Title:
PHARMACEUTICAL COMPOSITION CONTAINING LOW-DOSE APIXABAN
Document Type and Number:
WIPO Patent Application WO/2019/225467
Kind Code:
A1
Abstract:
This pharmaceutical composition is characterized by containing apixaban and by being used so that approximately 0.8 mg to approximately 1.5 mg of apixaban or a pharmacologically acceptable salt thereof or a solvate thereof per instance is administered to a patient twice or three times per day. The patient has atrial fibrillation and meets at least two of the following criteria (1)-(3): (1) age 80 years or more; (2) weight 60 kg or less; (3) serum creatinine concentration 1.5 mg/dL or higher.
Inventors:
HARA MASAHIKO (JP)
Application Number:
PCT/JP2019/019479
Publication Date:
November 28, 2019
Filing Date:
May 16, 2019
Export Citation:
Assignee:
RES MIND INC (JP)
International Classes:
A61K31/4545; A61P7/02; A61P9/06; A61P9/10
Other References:
"2. 1 Recommended Dose", ELIQUIES (APIXABAN) LABEL, 2016, pages 1 - 44
BARRA, M. E. ET AL.: "Evaluation of Dose-Reduced Direct Oral Anticoagulant Therapy", THE AMERICAN JOURNAL OF MEDICINE, vol. 129, no. 11, 2016, pages 1198 - 1204, XP029780237, ISSN: 0002-9343, DOI: 10.1016/j.amjmed.2016.05.041
BARRA, M. E. ET AL.: "Evaluation of Dose-Reduced Direct Oral Anticoagulant Therapy", THE AMERICAN JOURNAL OF MEDICINE, vol. 129, no. 11, 2016, pages 1198 - 1204, XP029780237, ISSN: 0002-9343, DOI: 10.1016/j.amjmed.2016.05.041
Attorney, Agent or Firm:
ISHIKAWA Toru et al. (JP)
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