Title:
PHARMACEUTICAL COMPOSITION CONTAINING MOR AGONIST AND KOR AGONIST, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/188641
Kind Code:
A1
Abstract:
Provided are uses of the combination of a μ opioid receptor (MOR) agonist and a κ opioid receptor (KOR) agonist in the preparation of drugs for relieving and/or treating pain. The MOR agonist is selected from the compound represented in formula (I), or a tautomer, mesomer, racemate, enantiomer or diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. Also provided is a pharmaceutical composition containing the MOR agonist and the KOR agonist.
Inventors:
NIU ZHUOLU (CN)
CAO GUOQING (CN)
YANG CHANGYONG (CN)
ZHANG LIANSHAN (CN)
CAO GUOQING (CN)
YANG CHANGYONG (CN)
ZHANG LIANSHAN (CN)
Application Number:
PCT/CN2018/082912
Publication Date:
October 18, 2018
Filing Date:
April 13, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
International Classes:
A61K31/4433; A61K31/443; A61K31/4436; A61K31/444; A61K31/45; A61P25/04
Domestic Patent References:
| WO2017063509A1 | 2017-04-20 | |||
| WO2017063509A1 | 2017-04-20 | |||
| WO2012129495A1 | 2012-09-27 | |||
| WO2008060552A2 | 2008-05-22 | |||
| WO2016073443A2 | 2016-05-12 | |||
| WO2008057608A2 | 2008-05-15 | |||
| WO2015065867A2 | 2015-05-07 | |||
| WO2006115353A1 | 2006-11-02 |
Foreign References:
| CN107098871A | 2017-08-29 | |||
| CN103702561A | 2014-04-02 | |||
| CN101627049A | 2010-01-13 | |||
| CN2016101064W | 2016-09-30 | |||
| CN107098871A | 2017-08-29 | |||
| CN201710095021A | 2017-02-22 | |||
| US20110212882A1 | 2011-09-01 |
Other References:
FUJITA-HAMABE ET AL., JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 62, no. 8, 2010, pages 995 - 1002
CUNHA TM ET AL., MOLECULAR PAIN, vol. 8, no. 1, 2012, pages 10
RONG LIU ET AL., CHINA PHARMACEUTICALS, vol. 25, no. 22, 2016, pages 41 - 44
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 45, no. 28, 2006, pages 4641 - 4644
TETRAHEDRON, vol. 58, no. 27, 2002, pages 5427 - 5439
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 64-17-5
See also references of EP 3610874A4
CUNHA TM ET AL., MOLECULAR PAIN, vol. 8, no. 1, 2012, pages 10
RONG LIU ET AL., CHINA PHARMACEUTICALS, vol. 25, no. 22, 2016, pages 41 - 44
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 45, no. 28, 2006, pages 4641 - 4644
TETRAHEDRON, vol. 58, no. 27, 2002, pages 5427 - 5439
CHEMICAL ABSTRACTS, Columbus, Ohio, US; abstract no. 64-17-5
See also references of EP 3610874A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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