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Patent Searching and Data


Title:
PHARMACEUTICAL COMPOSITION CONTAINING NICLOSAMIDE FOR TREATING OR PREVENTING CANCER RELATING TO Ras CANCER GENE-TARGETED THERAPY
Document Type and Number:
WIPO Patent Application WO/2018/128517
Kind Code:
A1
Abstract:
The present invention relates to: a composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for inhibiting Ras; and a pharmaceutical composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for treating cancer recurring due to Ras activation. According to the present invention, cancer recurring due to Ras activation can be effectively prevented or treated using niclosamide, which is a safe drug approved by the FDA.

Inventors:
YOOK JONG IN (KR)
KIM HYUN SIL (KR)
KIM NAM HEE (KR)
NO KYOUNG TAI (KR)
CHOI JI WON (KR)
AHN SUNG YONG (KR)
Application Number:
PCT/KR2018/000396
Publication Date:
July 12, 2018
Filing Date:
January 09, 2018
Export Citation:
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Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/167; A61K45/06
Domestic Patent References:
WO2012143377A12012-10-26
WO2004006906A22004-01-22
Foreign References:
US6989383B12006-01-24
Other References:
AHN, SUNG YONG: "Regulation of Cancer EMT by Axin-GSK3 Interaction Inhibitor", THE DOCTORAL DISSERTATION SUBMITTED TO THE DEPARTMENT OF APPLIED LIFE SCIENCE AND THE GRADUATE SCHOOL OF YONSEI UNIVERSITY, 2016
OSADA, T. ET AL.: "Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations", CANCER RESEARCH, vol. 71, no. 12, 15 June 2011 (2011-06-15), pages 4172 - 4182, XP055512953
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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