Title:
PHARMACEUTICAL COMPOSITION, CONTAINING NM23 ACTIVATOR, FOR INHIBITING CANCER METASTASIS
Document Type and Number:
WIPO Patent Application WO/2018/199727
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for inhibiting cancer metastasis, the pharmaceutical composition containing an activator compound of the cancer metastasis inhibitor Nm23, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, as an active ingredient. The compound according to the present invention inhibits the metastasis of cancer cells by stimulating the activity of Nm23 associated with cancer metastasis, and thus can be favorably used as a pharmaceutical composition for inhibiting cancer metastasis.
Inventors:
LEE KONG JOO (KR)
LEE HEE-YOON (KR)
LEE JE JIN (KR)
SEO EUN-KYOUNG (KR)
LEE EUN SUN (KR)
KIM HWANG SUK (KR)
LEE HONGSOO (KR)
LEE HEE-YOON (KR)
LEE JE JIN (KR)
SEO EUN-KYOUNG (KR)
LEE EUN SUN (KR)
KIM HWANG SUK (KR)
LEE HONGSOO (KR)
Application Number:
PCT/KR2018/005036
Publication Date:
November 01, 2018
Filing Date:
April 30, 2018
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61K31/085; A61K31/015
Other References:
ZHAO, D. -D. %: "Compounds from Dryopteris fragrans (L.) Schott with cytotoxic activity", MOLECULES, vol. 19, no. 3, 2014, pages 3345 - 3355, XP055531656
CHAE, S. W. %: "In vitro and in vivo evaluation of phenylbutenoid dimers as inhibitors of P-glycoprotein", JOURNAL OF NATURAL PRODUCTS, vol. 76, no. 12, 2013, pages 2277 - 2281, XP055531659
MATSUDA, H. %: "Invasion inhibitors of human fibrosarcoma HT 1080 cells from the rhizomes of Zingiber cassumunar: structures of phenylbutanoids, cassumunols", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 59, no. 3, 2011, pages 365 - 370, XP009193792
CHUNG, S. Y.: "Potent modulation of P-glycoprotein activity by naturally occurring phenylbutenoids from Zingiber cassumunar", PHYTOTHERAPY RESEARCH, vol. 23, no. 4, 2009, pages 472 - 476, XP055531666
KUROYANAGI, M.: "Further characterization of the constituents of a thai medicinal plant, Zingiber cassumunar Roxb", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 28, 1980, pages 2948 - 2959, XP055531671
See also references of EP 3616692A4
HORAK CE ET AL.: "The role of metastasis suppressor genes in metastatic dormancy", A PMIS, vol. 116, no. 7-8, July 2008 (2008-07-01), pages 586 - 601
LEE E ET AL.: "Multiple functions of Nm23-H1 are regulated by oxido reduction system", PLOS ONE, vol. 4, no. 11, 23 November 2009 (2009-11-23), pages e7949, XP055154142, DOI: 10.1371/journal.pone.0007949
PALMIERI D ET AL.: "Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer", J NATL CANCER INSL, vol. 97, no. 9, 4 May 2005 (2005-05-04), pages 632 - 42
LIMJ ET AL.: "Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis", CANCER RES., vol. 71, no. 23, 1 December 2011 (2011-12-01), pages 7216 - 25
C HU ET AL., J . NAT PROD., vol. 74, 2011, pages 1817
CHAE, S. W. %: "In vitro and in vivo evaluation of phenylbutenoid dimers as inhibitors of P-glycoprotein", JOURNAL OF NATURAL PRODUCTS, vol. 76, no. 12, 2013, pages 2277 - 2281, XP055531659
MATSUDA, H. %: "Invasion inhibitors of human fibrosarcoma HT 1080 cells from the rhizomes of Zingiber cassumunar: structures of phenylbutanoids, cassumunols", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 59, no. 3, 2011, pages 365 - 370, XP009193792
CHUNG, S. Y.: "Potent modulation of P-glycoprotein activity by naturally occurring phenylbutenoids from Zingiber cassumunar", PHYTOTHERAPY RESEARCH, vol. 23, no. 4, 2009, pages 472 - 476, XP055531666
KUROYANAGI, M.: "Further characterization of the constituents of a thai medicinal plant, Zingiber cassumunar Roxb", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 28, 1980, pages 2948 - 2959, XP055531671
See also references of EP 3616692A4
HORAK CE ET AL.: "The role of metastasis suppressor genes in metastatic dormancy", A PMIS, vol. 116, no. 7-8, July 2008 (2008-07-01), pages 586 - 601
LEE E ET AL.: "Multiple functions of Nm23-H1 are regulated by oxido reduction system", PLOS ONE, vol. 4, no. 11, 23 November 2009 (2009-11-23), pages e7949, XP055154142, DOI: 10.1371/journal.pone.0007949
PALMIERI D ET AL.: "Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer", J NATL CANCER INSL, vol. 97, no. 9, 4 May 2005 (2005-05-04), pages 632 - 42
LIMJ ET AL.: "Cell-permeable NM23 blocks the maintenance and progression of established pulmonary metastasis", CANCER RES., vol. 71, no. 23, 1 December 2011 (2011-12-01), pages 7216 - 25
C HU ET AL., J . NAT PROD., vol. 74, 2011, pages 1817
Attorney, Agent or Firm:
AHN, So Young (KR)
Download PDF: