Title:
PHARMACEUTICAL COMPOSITION CONTAINING NO, PROCESS FOR THE PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/131412
Kind Code:
A3
Abstract:
The invention relates to a pharmaceutical composition comprising NO, wherein the composition comprises as NO-source a zeolite-free transition metal complex, preferably a ferrous-nitroso-sulphate, furthermore one or more lipophil carrier(s) and optionally one or more pharmaceutically acceptable excipient(s). The invention further relates to the process for the preparation of the above-mentioned pharmaceutical composition, and the use thereof as a medicine.˙
Inventors:
SZABO LASZLO GABOR (HU)
PILLER ISTVAN (HU)
PILLER ISTVAN (HU)
Application Number:
PCT/HU2012/000023
Publication Date:
December 13, 2012
Filing Date:
March 30, 2012
Export Citation:
Assignee:
SZABO LASZLO GABOR (HU)
PILLER ISTVAN (HU)
PILLER ISTVAN (HU)
International Classes:
A61K31/04; A61K9/00; A61K33/04; A61K47/06; A61P9/10; A61P9/12; A61P17/06; A61P17/10; A61P25/24; A61P29/00; A61P31/00
Domestic Patent References:
| WO1994018966A1 | 1994-09-01 |
Other References:
JI B Q ET AL: "Study on transdermal sodium nitroprusside delivery system", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 28, no. 1-3, 1 January 1994 (1994-01-01), pages 279 - 281, XP025526680, ISSN: 0168-3659, [retrieved on 19940101], DOI: 10.1016/0168-3659(94)90180-5
CHRISTINA JÄGRÉN ET AL: "Skin microvascular dilatation response to acetylcholine and sodium nitroprusside in peripheral arterial disease", CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, vol. 22, no. 6, November 2002 (2002-11-01), pages 370 - 374, XP055038784, ISSN: 1475-0961, DOI: 10.1046/j.1475-097X.2002.00436.x
EROY-REVELES A A ET AL: "Nitric oxide-donating materials and their potential in pharmacological applications for site-specific nitric oxide delivery", FUTURE MEDICINAL CHEMISTRY, FUTURE SCIENCE LTD, GB, vol. 1, no. 8, November 2009 (2009-11-01), pages 1497 - 1507, XP009162990, ISSN: 1756-8919, DOI: 10.4155/FMC.09.111
VANIN ET AL: "Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology", NITRIC OXIDE: BIOLOGY AND CHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 21, no. 1, 1 August 2009 (2009-08-01), pages 1 - 13, XP026284010, ISSN: 1089-8603, [retrieved on 20090412], DOI: 10.1016/J.NIOX.2009.03.005
SEUNG NAMKOONG ET AL: "Therapeutic Application of Nitric Oxide in Human Diseases", BIOMOLECULES AND THERAPEUTICS, vol. 18, no. 4, 31 October 2010 (2010-10-31), pages 351 - 362, XP055038842, ISSN: 1976-9148, DOI: 10.4062/biomolther.2010.18.4.351
CHRISTINA JÄGRÉN ET AL: "Skin microvascular dilatation response to acetylcholine and sodium nitroprusside in peripheral arterial disease", CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, vol. 22, no. 6, November 2002 (2002-11-01), pages 370 - 374, XP055038784, ISSN: 1475-0961, DOI: 10.1046/j.1475-097X.2002.00436.x
EROY-REVELES A A ET AL: "Nitric oxide-donating materials and their potential in pharmacological applications for site-specific nitric oxide delivery", FUTURE MEDICINAL CHEMISTRY, FUTURE SCIENCE LTD, GB, vol. 1, no. 8, November 2009 (2009-11-01), pages 1497 - 1507, XP009162990, ISSN: 1756-8919, DOI: 10.4155/FMC.09.111
VANIN ET AL: "Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology", NITRIC OXIDE: BIOLOGY AND CHEMISTRY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 21, no. 1, 1 August 2009 (2009-08-01), pages 1 - 13, XP026284010, ISSN: 1089-8603, [retrieved on 20090412], DOI: 10.1016/J.NIOX.2009.03.005
SEUNG NAMKOONG ET AL: "Therapeutic Application of Nitric Oxide in Human Diseases", BIOMOLECULES AND THERAPEUTICS, vol. 18, no. 4, 31 October 2010 (2010-10-31), pages 351 - 362, XP055038842, ISSN: 1976-9148, DOI: 10.4062/biomolther.2010.18.4.351
Attorney, Agent or Firm:
DANUBIA PATENT & LAW OFFICE LLC (Budapest, HU)
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