Title:
PHARMACEUTICAL COMPOSITION CONTAINING PEITC AND USE THEREOF IN CANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO/2017/181943
Kind Code:
A1
Abstract:
Provided in the present invention is a use of PEITC for preparing a preparation or composition. The preparation or composition is used for: (a) altering the mutant p53 to restore the wild-type activity; (b) inhibiting the tumour cell proliferation caused by the mutant p53; (c) inducing apoptosis of mutant p53 tumour cells; and/or (d) preventing or treating diseases based on p53 mutations. Also provided in the present invention are a use of a p53 gene detection reagent, a kit comprising PEITC and the p53 gene detection reagent, and a method for non-therapeutically inhibiting tumour cells in vitro.
Inventors:
CHUNG FUNG-LUNG (US)
CHENG JINGCAI (CN)
AGGARWAL MONIKA (US)
CHENG JINGCAI (CN)
AGGARWAL MONIKA (US)
Application Number:
PCT/CN2017/080960
Publication Date:
October 26, 2017
Filing Date:
April 18, 2017
Export Citation:
Assignee:
JC (WUXI) COMPANY INC (CN)
International Classes:
A61K31/26; A61P35/00; G01N33/574; G01N33/68
Foreign References:
| US20130158111A1 | 2013-06-20 |
Other References:
WANG, XIANTAO ET AL.: "Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure - activity relationships", J MED CHEM., vol. 54, no. 3, 10 February 2011 (2011-02-10), pages 809 - 816, XP055602292, ISSN: 0022-2623, DOI: 10.1021/jm101199t
YAO-TSUNG: "Phenethyl isothiocyanate induces DNA damage-associated G2/ M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations", FREE RADICAL BIOLOGY AND MEDICINE, vol. 74, 19 June 2014 (2014-06-19), pages 1 - 13, XP055602296, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2014.06.008
YAO-TSUNG: "Phenethyl isothiocyanate induces DNA damage-associated G2/ M arrest and subsequent apoptosis in oral cancer cells with varying p53 mutations", FREE RADICAL BIOLOGY AND MEDICINE, vol. 74, 19 June 2014 (2014-06-19), pages 1 - 13, XP055602296, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2014.06.008
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
Download PDF: