PHARMACEUTICAL COMPOSITION CONTAINING STABILIZED ALTERED MITE PRINCIPAL ALLERGEN

Title:

PHARMACEUTICAL COMPOSITION CONTAINING STABILIZED ALTERED MITE PRINCIPAL ALLERGEN

Document Type and Number:

WIPO Patent Application WO/2006/001240

Kind Code:

A1

Abstract:

A stable pharmaceutical composition containing as an active ingredient an altered mite principal allergen obtained by a technology of genetic manipulation. Further, there is provided a process for producing a pharmaceutical composition for treatment of mite allergy disease, comprising mixing an altered mite principal allergen obtained by a technology of genetic manipulation as an active ingredient with Macrogol 4000 and/or Polysolvate 80 as an additive optionally together with sucrose and lyophilizing the mixture. Still further, there is provided a pharmaceutical composition produced by the above process.

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Inventors:

KOYANAGI SATOSHI (JP)
KAWATSU KENJIRO (JP)

Application Number:

PCT/JP2005/011233

Publication Date:

January 05, 2006

Filing Date:

June 20, 2005

Export Citation:

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Assignee:

CHEMO SERO THERAPEUT RES INST (JP)
KOYANAGI SATOSHI (JP)
KAWATSU KENJIRO (JP)

International Classes:

A61K39/00; A61K47/26; A61K47/34; A61K9/19; A61P11/02; A61P11/06; A61P17/04; A61P27/14; A61P37/08; C12N15/09; (IPC1-7): A61K39/00; A61K9/19; A61K47/26; A61K47/34; A61P11/02; A61P11/06; A61P17/04; A61P27/14; A61P37/08; C12N15/09

Foreign References:

JPH06253851A	1994-09-13
JPH08507064A	1996-07-30
JP2001192343A	2001-07-17
JP2001503781A	2001-03-21
JP2000515856A	2000-11-28

Other References:

ARAKAWA C. ET AL.: "Fukusu no Stress ni yoru Tanpakushitsu no Kaigo ni Oyobosu Anteikazai no Sayo", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 123, no. 11, 2003, pages 957 - 961
ARAKAWA T. ET AL.: "Protein-Solvent Interactions in Pharmaceutical Formulation", PHARMACEUTICAL RESEARCH, vol. 8, no. 3, 1991, pages 285 - 291, XP009052919, DOI: doi:10.1023/A:1015825027737

Attorney, Agent or Firm:

Kawamiya, Osamu (IMP Building 3-7, Shiromi 1-chome, Chuo-ku, Osaka-shi Osaka, JP)

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