Title:
PHARMACEUTICAL COMPOSITION FOR ENHANCING BIOAVAILABILITY OF DRUG FOR TREATMENT OF ACNE
Document Type and Number:
WIPO Patent Application WO/2018/080284
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising retinoid and benzoyl peroxide and, more specifically, to a pharmaceutical composition for treating acne with enhanced bioavailability in the form of a cream gel comprising adapalene and dispersed benzoyl peroxide. The pharmaceutical composition according to the present invention is excellent in skin affinity as the composition contains pseudoceramides which are very similar to natural ceramides, and has an effect of improving skin usability such as the stability of the product, skin moisturizing power and feeling of use, skin barrier formation and the like as the composition contains a multilamellar emulsion which is very similar to a lamellar structure which is a lipid structure between dermal keratinocytes. In addition, the pharmaceutical composition according to the present invention is non-toxic and has an excellent therapeutic effect on acne lesions without inducing skin irritation.
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Inventors:
KIM YUN-SIK (KR)
KIM HAN-GYU (KR)
CHOO EUI-JIN (KR)
MOON SE-HUI (KR)
KIM HAN-GYU (KR)
CHOO EUI-JIN (KR)
MOON SE-HUI (KR)
Application Number:
PCT/KR2017/012181
Publication Date:
May 03, 2018
Filing Date:
October 31, 2017
Export Citation:
Assignee:
DONGKOO BIO & PHARMA CO LTD (KR)
International Classes:
A61K31/192; A61K31/21
Foreign References:
| KR20150003917A | 2015-01-09 | |||
| KR20150003685A | 2015-01-09 | |||
| KR101014586B1 | 2011-02-16 | |||
| KR20120041294A | 2012-05-02 | |||
| KR20140070430A | 2014-06-10 |
Attorney, Agent or Firm:
SON, Seung-hee (KR)
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