Title:
PHARMACEUTICAL COMPOSITION FOR ENHANCING RADIATION THERAPY FOR CANCER, AND METHOD FOR SCREENING ACTIVE MATERIAL FOR ENHANCING RADIATION THERAPY FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2011/013912
Kind Code:
A2
Abstract:
The present invention relates to a pharmaceutical composition for enhancing radiation therapy for cancer, containing a functional inhibitor for the association of the Snail 1 protein transcription factor with DNA-PKcs. The present invention also relates to a method for screening an active material for enhancing radiation therapy for cancer, including the step of: selecting a sample which inhibits the expression of the Snail1 gene in a cancer cell line; or selecting a sample which inhibits the association of Snail1 with DNA-PKcs.
Inventors:
LEE YUN SIL (KR)
SEO HAENG RAN (KR)
SEO HAENG RAN (KR)
Application Number:
PCT/KR2010/004267
Publication Date:
February 03, 2011
Filing Date:
July 01, 2010
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
LEE YUN SIL (KR)
SEO HAENG RAN (KR)
LEE YUN SIL (KR)
SEO HAENG RAN (KR)
International Classes:
A61K31/7088; A61K38/08; A61K38/16; A61P35/00
Other References:
MARIA ESCRIVA ET AL.: 'Repression of PTEN phosphatase by Snail 1 transcriptional factor during gamma radiation-induced apoptosis.' MOLECULAR AND CELLULAR BIOLOGY vol. 28, no. 5, 2008, pages 1528 - 1540
SONIA VEGA ET AL.: 'Snail blocks the cell cycle and confers resistance to cell death.' GENES & DEVELOPMENT vol. 18, no. 10, 2004, pages 1131 - 1143, XP002359814
MASAHIRO KAJITA ET AL.: 'Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.' MOLECULAR AND CELLULAR BIOLOGY vol. 24, no. 17, 2004, pages 7559 - 7566, XP002359815
ALEJANDRO BARRALLO-GIMENO ET AL.: 'The Snail genes as inducers of cell movement and survival: implications in development and cancer.' DEVELOPMENT vol. 132, no. 14, 2005, pages 3151 - 3161, XP009059098
SONIA VEGA ET AL.: 'Snail blocks the cell cycle and confers resistance to cell death.' GENES & DEVELOPMENT vol. 18, no. 10, 2004, pages 1131 - 1143, XP002359814
MASAHIRO KAJITA ET AL.: 'Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress.' MOLECULAR AND CELLULAR BIOLOGY vol. 24, no. 17, 2004, pages 7559 - 7566, XP002359815
ALEJANDRO BARRALLO-GIMENO ET AL.: 'The Snail genes as inducers of cell movement and survival: implications in development and cancer.' DEVELOPMENT vol. 132, no. 14, 2005, pages 3151 - 3161, XP009059098
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
리앤목특허법인 (KR)
리앤목특허법인 (KR)
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