Login| Sign Up| Help| Contact|

Patent Searching and Data

Document Type and Number:
WIPO Patent Application WO/2017/208869
Kind Code:
The purpose of the present invention is to provide a pharmaceutical composition and a food which have the effect of preventing central nervous system diseases and inhibiting the advancement thereof. This pharmaceutical composition is used to prevent and treat central nervous system diseases, and includes a butanol extract of the peel of the fruit of the Ponkan, which is a citrus plant. As a result of including the butanol extract, the present invention is capable of improving the luciferase activity of PC12 cells, and can prevent central nervous system diseases and inhibit the advancement thereof.

OHIZUMI Yasushi (6-25-20, Kunimi Aoba-ku, Sendai-sh, Miyagi 43, 〒9810943, JP)
KAJIMA Koji (255-10, Nakajima Fuji-sh, Shizuoka 07, 〒4160907, JP)
MARUYAMA Koji (14-39, Imaizumi 6-chome Fuji-sh, Shizuoka 01, 〒4170001, JP)
ISHIBASHI Masami (3-9 Onaridai 1-chome, Wakaba-ku Chiba-sh, Chiba 77, 〒2650077, JP)
Application Number:
Publication Date:
December 07, 2017
Filing Date:
May 19, 2017
Export Citation:
Click for automatic bibliography generation   Help
SANKYO HOLDINGS CO., LTD. (573-13, Denbo Fuji-sh, Shizuoka 61, 〒4170061, JP)
OHIZUMI Yasushi (6-25-20, Kunimi Aoba-ku, Sendai-sh, Miyagi 43, 〒9810943, JP)
SENDAN GAKUEN EDUCATIONAL CORPORATION (8-1 Kunimi 1-chome, Aoba-ku Sendai-sh, Miyagi 43, 〒9810943, JP)
International Classes:
A61K36/752; A23L33/105; A61K31/353; A61P25/00; A61P25/28; A61P43/00
Foreign References:
Other References:
SINGH JAGDEEP ET AL.: "In-vitro evaluation of bioactive compounds, anti-oxidan t , lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna", L. PEEL EXTRACT, J FOOD SCI TECHNOL, vol. 51, no. 1, 2014, pages 67 - 74, XP055444362
LUO XIAOTING ET AL.: "Effect of hesperidin extraction on cell proliferation and apoptosis of Alzheimer's disease induced by Abeta25-35", INTERNATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING AND INFORMATICS, vol. 5, 2010, pages 2020 - 2023, XP031804158
WANG DONG-MEI ET AL.: "Protective effects of hesperidin against amyloid-beta induced neurotoxicity through the voltage dependent anion channel1(VDAC1)-mediated mitochondrial apoptotic pathway in PC12 cells", NEUROCHEMICAL RESEARCH, vol. 38, no. 5, 1 May 2013 (2013-05-01), pages 1034 - 1044, XP055345092
NAGASE HIROYUKI ET AL.: "Mechanism of neurotrophic action of nobiletin in PC12D cells", BIOCHEMISTRY, vol. 44, 2005, pages 13683 - 13691, XP055444382
WANG DONG-MEI ET AL.: "Naringin enhances CaMKII activity and improves long-term memory in a mouse model of Alzheimer's disease", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 14, 2013, pages 5576 - 5586, XP055366278
Attorney, Agent or Firm:
FUKUDA Shinichi et al. (Kashiwaya Bldg. 6-13, Nishishinbashi 1-chome Minato-ku Tokyo, 03, 〒1050003, JP)
Download PDF: