Title:
PHARMACEUTICAL COMPOSITION IN WHICH SOLUBILITY OF PARTIALLY SOLUBLE TRICYCLIC DERIVATIVE IS IMPROVED
Document Type and Number:
WIPO Patent Application WO/2011/162560
Kind Code:
A2
Abstract:
The present invention relates to a pharmaceutical composition comprising a phospholipid, cholesterol, an ionic lipid, and nanoparticles comprising a tricyclic derivative, wherein the solubility of the tricyclic derivative is improved. According to the present invention, it is possible to solubilize a partially soluble tricyclic derivative in a high concentration even without using a solubilization aid harmful to the human body, to maintain improved solubility even if water is added for the use as an injection, and to show stability even if stored for a long time, by preparing lipid nanoparticles. Therefore, the lipid nanoparticles of the present invention can be used for preparing a pharmaceutical preparation containing a partially soluble tricyclic derivative as an active ingredient.
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Inventors:
KIM MYUNG-HWA (KR)
CHUN KWANG-WOO (KR)
YE IN-HAE (KR)
CHOI JONG-HEE (KR)
CHUN KWANG-WOO (KR)
YE IN-HAE (KR)
CHOI JONG-HEE (KR)
Application Number:
PCT/KR2011/004600
Publication Date:
December 29, 2011
Filing Date:
June 23, 2011
Export Citation:
Assignee:
JEIL PHARMACEUTICAL CO LTD (KR)
KIM MYUNG-HWA (KR)
CHUN KWANG-WOO (KR)
YE IN-HAE (KR)
CHOI JONG-HEE (KR)
KIM MYUNG-HWA (KR)
CHUN KWANG-WOO (KR)
YE IN-HAE (KR)
CHOI JONG-HEE (KR)
International Classes:
A61K31/01; A61K9/16; A61K9/20; A61K9/48; A61K31/66
Domestic Patent References:
| WO1997001570A1 | 1997-01-16 |
Foreign References:
| KR100667464B1 | 2007-01-10 | |||
| US6080739A | 2000-06-27 | |||
| US20040247660A1 | 2004-12-09 |
Other References:
See references of EP 2586430A4
Attorney, Agent or Firm:
LEE, Won Hee (642-16Yoksam-dong, Kangnam-ku, Seoul 135-080, KR)
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Claims: