Title:
PHARMACEUTICAL COMPOSITION FOR INHIBITING ANGIOGENESIS CONTAINING PLANT-DERIVED NATURAL COMPOUND
Document Type and Number:
WIPO Patent Application WO/2013/081374
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for inhibiting angiogenesis containing a plant-derived natural compound which can be effective for preventing or treating disorders or diseases associated with angiogenesis. The compound used as an active ingredient in the pharmaceutical composition of the present invention suppresses VEGF-induced angiogenic responses without cytotoxicity at a low concentration by inhibiting the expression of an angiogenesis inhibitory factor (for example, VEGF), and thus remarkably improves the safety of a drug.
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Inventors:
KWON HO JEONG (KR)
KIM YONG HYO (KR)
KIM YONG HYO (KR)
Application Number:
PCT/KR2012/010181
Publication Date:
June 06, 2013
Filing Date:
November 28, 2012
Export Citation:
Assignee:
UNIV YONSEI IACF (KR)
International Classes:
A61K31/55; A61K31/407; A61K31/5517; A61P35/00
Domestic Patent References:
| WO1999048501A1 | 1999-09-30 |
Other References:
PEREIRA, C. G. ET AL.: "Anticancer activity of Tabernaemontana catharinensis extract obtained by supercritical fluid extraction", REV. BRAS. PL. MED., BOTUCATU, vol. 8, no. 4, 2006, pages 144 - 149
JIN, Y.-S. ET AL.: "A new indole alkaloid from Ervatamia yunnanensis", FITOTERAPIA, vol. 81, 2010, pages 63 - 65, XP026764062, DOI: doi:10.1016/j.fitote.2009.07.008
JIN, Y.-S. ET AL.: "A new indole alkaloid from Ervatamia yunnanensis", FITOTERAPIA, vol. 81, 2010, pages 63 - 65, XP026764062, DOI: doi:10.1016/j.fitote.2009.07.008
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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Claims: