Title:
PHARMACEUTICAL COMPOSITION FOR INHIBITING PRODUCTION OF HEPATITIS B VIRUS PROTEIN, AND METHOD FOR SCREENING SAME
Document Type and Number:
WIPO Patent Application WO/2020/196737
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a pharmaceutical composition useful as a novel hepatitis B antiviral agent and a method for screening the same. According to the present invention, provided is a pharmaceutical composition for inhibiting the production of hepatitis B virus proteins, the pharmaceutical composition being characterized by inhibiting the expression or function of an RNA-binding protein which is bound to at least one sequence selected from an RNA sequence of a hepatitis B virus corresponding to the sequence of an enhancer I region on a hepatitis B virus genome DNA and an RNA sequence of a hepatitis B virus corresponding to the sequence of an enhancer II region on the hepatitis B virus genome DNA.
Inventors:
TANAKA YASUHITO (JP)
HABA RYOTA (JP)
SHIMANE KAZUKI (JP)
KAWANO TAKAKI (JP)
HABA RYOTA (JP)
SHIMANE KAZUKI (JP)
KAWANO TAKAKI (JP)
Application Number:
PCT/JP2020/013624
Publication Date:
October 01, 2020
Filing Date:
March 26, 2020
Export Citation:
Assignee:
FUJIFILM CORP (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
International Classes:
A61K39/395; A61K31/7088; A61K31/713; A61K35/76; A61K38/02; A61K45/00; A61P1/16; A61P31/20; A61P43/00; C12N15/09; C12N15/113; C12N15/864; C12Q1/686; G01N33/15; G01N33/50
Domestic Patent References:
| WO2015133613A1 | 2015-09-11 | |||
| WO2005059138A1 | 2005-06-30 |
Foreign References:
| CN1631442A | 2005-06-29 | |||
| US20030148985A1 | 2003-08-07 | |||
| JP2018526332A | 2018-09-13 | |||
| JP2007520461A | 2007-07-26 | |||
| JP2005532052A | 2005-10-27 |
Other References:
LI, Y. ET AL.: "LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity", SCIENTIFIC REP., vol. 6, 2016, pages 1 - 11, XP055743291
COOK, KB. ET AL.: "RBPDB: a database of RNA-binding specificities", NUC ACI RES., vol. 39, 2011, pages D301 - D308, XP055743297
IIJIMA, SAYUKI ET AL.: "Reviews 4. Reverse Genetics of Hepatitis B virus", UIRUSU, vol. 63, no. 1, 2013, pages 23 - 32, XP055853866
TANAKA ET AL., MODERN MEDIA, vol. 54, no. 12, 2008, pages 347 - 352
BROUW ET AL., IMMUNOLOGY, vol. 126, 2008, pages 280 - 289
VANLANDSCHOOT ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 83, 2002, pages 1281 - 1289
WOODDELL ET AL., MOLECULAR THERAP, vol. 21, no. 5, 2013, pages 973 - 985
WU ET AL., GASTROENTEROLOGY, vol. 128, 2005, pages 708 - 716
RAY ET AL., NATURE, vol. 499, no. 11, 2013
SHARP ET AL., SCIENCE, vol. 287, 2000, pages 2431 - 2432
ZAMORE ET AL., CELL, vol. 101, 2000, pages 25 - 33
TUSCHL ET AL., GENES & DEVELOPMENT, vol. 13, 1999, pages 3191 - 3197
OZAWA ET AL., DRUG DELIVERY SYSTEM, vol. 22, no. 6, 2007, pages 643 - 650
JINEK ET AL., SCIENCE, vol. 337, 2012, pages 816 - 821
PROC NATL ACAD SCI USA, vol. 84, 1987, pages 1005 - 1009
"GenBank", Database accession no. AB246345
NUCLEIC ACIDS RES, vol. 39, 2011, pages D301 - D308
See also references of EP 3949986A4
COOK, KB. ET AL.: "RBPDB: a database of RNA-binding specificities", NUC ACI RES., vol. 39, 2011, pages D301 - D308, XP055743297
IIJIMA, SAYUKI ET AL.: "Reviews 4. Reverse Genetics of Hepatitis B virus", UIRUSU, vol. 63, no. 1, 2013, pages 23 - 32, XP055853866
TANAKA ET AL., MODERN MEDIA, vol. 54, no. 12, 2008, pages 347 - 352
BROUW ET AL., IMMUNOLOGY, vol. 126, 2008, pages 280 - 289
VANLANDSCHOOT ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 83, 2002, pages 1281 - 1289
WOODDELL ET AL., MOLECULAR THERAP, vol. 21, no. 5, 2013, pages 973 - 985
WU ET AL., GASTROENTEROLOGY, vol. 128, 2005, pages 708 - 716
RAY ET AL., NATURE, vol. 499, no. 11, 2013
SHARP ET AL., SCIENCE, vol. 287, 2000, pages 2431 - 2432
ZAMORE ET AL., CELL, vol. 101, 2000, pages 25 - 33
TUSCHL ET AL., GENES & DEVELOPMENT, vol. 13, 1999, pages 3191 - 3197
OZAWA ET AL., DRUG DELIVERY SYSTEM, vol. 22, no. 6, 2007, pages 643 - 650
JINEK ET AL., SCIENCE, vol. 337, 2012, pages 816 - 821
PROC NATL ACAD SCI USA, vol. 84, 1987, pages 1005 - 1009
"GenBank", Database accession no. AB246345
NUCLEIC ACIDS RES, vol. 39, 2011, pages D301 - D308
See also references of EP 3949986A4
Attorney, Agent or Firm:
SIKS & CO. (JP)
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