Title:
PHARMACEUTICAL COMPOSITION INTENDED TO BE ADMINISTRED TO NASAL MUCOSA
Document Type and Number:
WIPO Patent Application WO/2017/073798
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing nasal drops which can achieve high absorption of oxytocin, which is a peptide hormone, an acid addition salt of oxytocin or a derivative of oxytocin or the acid addition salt through a nasal mucosa and which has less concerns about safety. The present invention is a pharmaceutical composition intended to be administered to a nasal mucosa, characterized by comprising oxytocin, an acid addition salt of oxytocin or a derivative of oxytocin or the acid addition salt and a carboxyvinyl polymer and having an osmotic pressure ratio of less than 1.
Inventors:
MARUO SUSUMU (JP)
NAGANO ATSUHIRO (JP)
NONAKA YUKO (JP)
FURUKAWA RYO (JP)
NAGANO ATSUHIRO (JP)
NONAKA YUKO (JP)
FURUKAWA RYO (JP)
Application Number:
PCT/JP2016/082897
Publication Date:
May 04, 2017
Filing Date:
October 28, 2016
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
A61K38/00; A61K9/08; A61K38/095; A61K47/32; A61P5/10
Foreign References:
| JP2014515747A | 2014-07-03 | |||
| JP2015120650A | 2015-07-02 |
Other References:
KETOUSETUO KUOTSU ET AL.: "Development of Oxytocin Nasal Gel Using Natural Mucoadhesive Agent Obtained from the Fruits of Dellinia indica.L.", SCIENCEASIA, vol. 33, 2007, pages 57 - 60, XP055381184
H.J.LEWIS ET AL.: "In-Vitro Investigation of the Potential of Mucoadhesive Micro Spheres for the Controlled Nasal Delivery of Oxytocin.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 42, no. Sl, 1990, pages 142P, XP055381186
POOJA JANI ET AL.: "Pharmaceutical Approaches Related to Systemic Delivery of Protein and Peptide Drugs:an Overview.", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH., vol. 12, no. 1, 2012, pages 42 - 52, XP055381188
See also references of EP 3369429A4
H.J.LEWIS ET AL.: "In-Vitro Investigation of the Potential of Mucoadhesive Micro Spheres for the Controlled Nasal Delivery of Oxytocin.", JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 42, no. Sl, 1990, pages 142P, XP055381186
POOJA JANI ET AL.: "Pharmaceutical Approaches Related to Systemic Delivery of Protein and Peptide Drugs:an Overview.", INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES REVIEW AND RESEARCH., vol. 12, no. 1, 2012, pages 42 - 52, XP055381188
See also references of EP 3369429A4
Attorney, Agent or Firm:
TAMEYAMA, Taro (JP)
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