Title:
PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2016/175230
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4- methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2- yl)carbamoyl]pyrazin-2-yl}piperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the medicinal substance are improved.
More Like This:
| JP2024508908 | PPARG inverse agonists and their uses |
| JP2021519269 | Piperazine azaspiro derivative |
| JP2024510247 | Heterocyclic derivatives as Janus kinase inhibitors |
Inventors:
SUDA YUMIKO (JP)
SAKAI TOSHIRO (JP)
KOJIMA RYO (JP)
OYAMA DAI (JP)
NISHIMURA KOJI (JP)
NAIKI KUMI (JP)
SAKAI TOSHIRO (JP)
KOJIMA RYO (JP)
OYAMA DAI (JP)
NISHIMURA KOJI (JP)
NAIKI KUMI (JP)
Application Number:
PCT/JP2016/063151
Publication Date:
November 03, 2016
Filing Date:
April 27, 2016
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
A61K31/497; A61K9/20; A61K9/46; A61K47/02; A61K47/26; A61K47/38; A61P13/02; A61P43/00
Domestic Patent References:
| WO2014133056A1 | 2014-09-04 | |||
| WO1998029137A1 | 1998-07-09 |
Other References:
DATABASE REGISTRY September 2014 (2014-09-01), XP055494705, retrieved from STN Database accession no. 1624297- 26-2
KAJIYAMA, ATSUSHI ET AL.: "Improvement of HPMC Tablet Disintegration by the Addition of Inorganic Salts", CHEM. PHARM. BULL., vol. 56, no. 4, 2008, pages 598 - 601, XP055327107, ISSN: 0009-2363
HAJIME KONNO ET AL.: "Stabilization Effect of Polymers on Solid Dispersions against Crystallization", JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 71, no. 2, 2011, Japan, pages 109 - 113, XP009506964, ISSN: 2188-3149
SUZUKI, HIDESHI ET AL.: "Influence of Water- Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers", CHEM. PHARM. BULL., vol. 46, no. 3, 1998, pages 482 - 487, XP000748996, ISSN: 0009-2363
KUMPRAKOB, USANEE ET AL.: "Permeation Enhancement of Ketoprofen Using a Supersaturated System with Antinucleant Polymers", BIOL. PHARM. BULL., vol. 28, no. 9, 2005, pages 1684 - 1688, XP055327110, ISSN: 1347-5215
BEAK, IN-HWAN ET AL.: "Improved Supersaturation and Oral Absorption of Dutasteride by Amorphous Solid Dispersions", CHEM. PHARM. BULL., vol. 60, no. 11, 2012, pages 1468 - 1473, XP055161211, ISSN: 0009-2363
See also references of EP 3290037A4
KAJIYAMA, ATSUSHI ET AL.: "Improvement of HPMC Tablet Disintegration by the Addition of Inorganic Salts", CHEM. PHARM. BULL., vol. 56, no. 4, 2008, pages 598 - 601, XP055327107, ISSN: 0009-2363
HAJIME KONNO ET AL.: "Stabilization Effect of Polymers on Solid Dispersions against Crystallization", JOURNAL OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, vol. 71, no. 2, 2011, Japan, pages 109 - 113, XP009506964, ISSN: 2188-3149
SUZUKI, HIDESHI ET AL.: "Influence of Water- Soluble Polymers on the Dissolution of Nifedipine Solid Dispersions with Combined Carriers", CHEM. PHARM. BULL., vol. 46, no. 3, 1998, pages 482 - 487, XP000748996, ISSN: 0009-2363
KUMPRAKOB, USANEE ET AL.: "Permeation Enhancement of Ketoprofen Using a Supersaturated System with Antinucleant Polymers", BIOL. PHARM. BULL., vol. 28, no. 9, 2005, pages 1684 - 1688, XP055327110, ISSN: 1347-5215
BEAK, IN-HWAN ET AL.: "Improved Supersaturation and Oral Absorption of Dutasteride by Amorphous Solid Dispersions", CHEM. PHARM. BULL., vol. 60, no. 11, 2012, pages 1468 - 1473, XP055161211, ISSN: 0009-2363
See also references of EP 3290037A4
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
Download PDF:
Previous Patent: LIQUID ENCAPSULATION CARTRIDGE, SAMPLE ANALYSIS DEVICE, AND SAMPLE ANALYSIS METHOD
Next Patent: FUEL CELL STACK
Next Patent: FUEL CELL STACK