Title:
PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION INCLUDING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
Document Type and Number:
WIPO Patent Application WO/2017/146052
Kind Code:
A1
Abstract:
Provided are: pharmaceutical composition particles and an orally disintegrating tablet including the same which are capable of achieving both the masking of unpalatable taste and an improvement in elution properties; and a method for producing pharmaceutical composition particles. This pharmaceutical composition particle comprises: a core particle including a drug; an intermediate layer that includes a gelling-swelling substance and that covers the outer side of the core particle; and an outermost layer that includes a water-insoluble substance and that covers the outer side of the intermediate layer. This method for producing pharmaceutical composition particles comprises: a pulverization step for pulverizing a gelling-swelling substance to an average particle diameter of 15 µm or smaller; a suspension step for suspending, in an organic solvent, the gelling-swelling substance pulverized in the pulverization step, to obtain a suspension; an intermediate layer forming step for spraying the suspension obtained in the suspension step onto a core particle including a drug, to form an intermediate layer on the outer side of the core particle; and an outer layer forming step for covering the outer side of the intermediate layer with a water-insoluble substance, to form an outer layer.
Inventors:
HAYASHIDA TOMOHIRO (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
Application Number:
PCT/JP2017/006388
Publication Date:
August 31, 2017
Filing Date:
February 21, 2017
Export Citation:
Assignee:
NIPRO CORP (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K9/14; A61K9/20; A61K31/135; A61K31/136; A61K31/445; A61K47/10; A61K47/32; A61K47/38
Domestic Patent References:
WO2007010930A1 | 2007-01-25 |
Foreign References:
JPH0772130B2 | 1995-08-02 | |||
JP2008037863A | 2008-02-21 | |||
JP2009545560A | 2009-12-24 | |||
JP2011513204A | 2011-04-28 | |||
JP2001526213A | 2001-12-18 | |||
JP2007153884A | 2007-06-21 |
Other References:
See also references of EP 3421032A4
Attorney, Agent or Firm:
AKAOKA Kazuo et al. (JP)
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