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Title:
PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION INCLUDING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
Document Type and Number:
WIPO Patent Application WO/2017/146052
Kind Code:
A1
Abstract:
Provided are: pharmaceutical composition particles and an orally disintegrating tablet including the same which are capable of achieving both the masking of unpalatable taste and an improvement in elution properties; and a method for producing pharmaceutical composition particles. This pharmaceutical composition particle comprises: a core particle including a drug; an intermediate layer that includes a gelling-swelling substance and that covers the outer side of the core particle; and an outermost layer that includes a water-insoluble substance and that covers the outer side of the intermediate layer. This method for producing pharmaceutical composition particles comprises: a pulverization step for pulverizing a gelling-swelling substance to an average particle diameter of 15 µm or smaller; a suspension step for suspending, in an organic solvent, the gelling-swelling substance pulverized in the pulverization step, to obtain a suspension; an intermediate layer forming step for spraying the suspension obtained in the suspension step onto a core particle including a drug, to form an intermediate layer on the outer side of the core particle; and an outer layer forming step for covering the outer side of the intermediate layer with a water-insoluble substance, to form an outer layer.

Inventors:
HAYASHIDA TOMOHIRO (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
Application Number:
PCT/JP2017/006388
Publication Date:
August 31, 2017
Filing Date:
February 21, 2017
Export Citation:
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Assignee:
NIPRO CORP (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K9/14; A61K9/20; A61K31/135; A61K31/136; A61K31/445; A61K47/10; A61K47/32; A61K47/38
Domestic Patent References:
WO2007010930A12007-01-25
Foreign References:
JPH0772130B21995-08-02
JP2008037863A2008-02-21
JP2009545560A2009-12-24
JP2011513204A2011-04-28
JP2001526213A2001-12-18
JP2007153884A2007-06-21
Other References:
See also references of EP 3421032A4
Attorney, Agent or Firm:
AKAOKA Kazuo et al. (JP)
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