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Title:
PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION INCLUDING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
Document Type and Number:
WIPO Patent Application WO/2017/146052
Kind Code:
A1
Abstract:
Provided are: pharmaceutical composition particles and an orally disintegrating tablet including the same which are capable of achieving both the masking of unpalatable taste and an improvement in elution properties; and a method for producing pharmaceutical composition particles. This pharmaceutical composition particle comprises: a core particle including a drug; an intermediate layer that includes a gelling-swelling substance and that covers the outer side of the core particle; and an outermost layer that includes a water-insoluble substance and that covers the outer side of the intermediate layer. This method for producing pharmaceutical composition particles comprises: a pulverization step for pulverizing a gelling-swelling substance to an average particle diameter of 15 µm or smaller; a suspension step for suspending, in an organic solvent, the gelling-swelling substance pulverized in the pulverization step, to obtain a suspension; an intermediate layer forming step for spraying the suspension obtained in the suspension step onto a core particle including a drug, to form an intermediate layer on the outer side of the core particle; and an outer layer forming step for covering the outer side of the intermediate layer with a water-insoluble substance, to form an outer layer.

Inventors:
HAYASHIDA Tomohiro (3023 Nojicho Kusatsu-sh, Shiga 55, 〒5250055, JP)
HOASHI Yohei (3023 Nojicho Kusatsu-sh, Shiga 55, 〒5250055, JP)
IJITSU Shin (3023 Nojicho Kusatsu-sh, Shiga 55, 〒5250055, JP)
NAKANO Yoshio (380, Mita-cho, Kishiwada-sh, Osaka 08, 〒5960808, JP)
YAMAZAKI Junji (380, Mita-cho, Kishiwada-sh, Osaka 08, 〒5960808, JP)
INOUE Katsuhisa (380, Mita-cho, Kishiwada-sh, Osaka 08, 〒5960808, JP)
AIZAWA Atsushi (380, Mita-cho, Kishiwada-sh, Osaka 08, 〒5960808, JP)
Application Number:
JP2017/006388
Publication Date:
August 31, 2017
Filing Date:
February 21, 2017
Export Citation:
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Assignee:
NIPRO CORPORATION (9-3 Honjo-nishi 3-chome, Kita-ku Osaka-sh, Osaka 10, 〒5318510, JP)
ZENSEI PHARMACEUTICAL INDUSTRIES CO.,LTD. (94-2, Hiraoka-cho Nishi-ku, Sakai-sh, Osaka 07, 〒5938307, JP)
International Classes:
A61K9/14; A61K9/20; A61K31/135; A61K31/136; A61K31/445; A61K47/10; A61K47/32; A61K47/38
Domestic Patent References:
WO2007010930A12007-01-25
Foreign References:
JPH0772130B21995-08-02
JP2008037863A2008-02-21
JP2009545560A2009-12-24
JP2011513204A2011-04-28
JP2001526213A2001-12-18
JP2007153884A2007-06-21
Attorney, Agent or Firm:
AKAOKA Kazuo et al. (Koei Building 5F, 1-13 Awajimachi 2-chome, Chuo-k, Osaka-shi Osaka 47, 〒5410047, JP)
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