Title:
PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION CONTAINING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
Document Type and Number:
WIPO Patent Application WO/2019/039420
Kind Code:
A1
Abstract:
Provided are: pharmaceutical composition particles for which both of the masking of the unpleasant taste thereof and the improvement in the elution properties thereof can be achieved; orally disintegrating tablets each containing the pharmaceutical composition particles; and a method for producing pharmaceutical composition particles. Each of the pharmaceutical composition particles comprises a core particle containing a drug and a water-soluble gelatinizable/swellable substance and an outer layer that contains a water-insoluble substance and coats the outside of the core particle. The method for producing pharmaceutical composition particles according to the present invention comprises: a pulverization step of pulverizing a water-soluble gelatinizable/swellable substance so that the pulverized product can have an average particle diameter of 15 μm or less; a core particle production step of mixing the gelatinizable/swellable substance pulverized in the pulverization step with a drug to produce core particles; and outer layer formation step of coating the outside of each of the core particles with a water-insoluble substance to form an outer layer.
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Inventors:
HAYASHIDA TOMOHIRO (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
Application Number:
PCT/JP2018/030618
Publication Date:
February 28, 2019
Filing Date:
August 20, 2018
Export Citation:
Assignee:
NIPRO CORP (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K9/20
Domestic Patent References:
WO2014181390A1 | 2014-11-13 | |||
WO2005039542A1 | 2005-05-06 | |||
WO2017146053A1 | 2017-08-31 | |||
WO2017146052A1 | 2017-08-31 | |||
WO2002096392A1 | 2002-12-05 | |||
WO2012036078A1 | 2012-03-22 |
Foreign References:
JP2004231520A | 2004-08-19 | |||
JP2002212062A | 2002-07-31 | |||
JP2010532384A | 2010-10-07 | |||
JP2007063263A | 2007-03-15 | |||
JP2008214334A | 2008-09-18 | |||
JP2008260712A | 2008-10-30 | |||
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JP2000191519A | 2000-07-11 | |||
JP2011225468A | 2011-11-10 | |||
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Other References:
See also references of EP 3673901A4
Attorney, Agent or Firm:
AKAOKA Kazuo et al. (JP)
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