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Title:
PHARMACEUTICAL COMPOSITION PARTICLES, ORALLY DISINTEGRATING PREPARATION CONTAINING SAME, AND METHOD FOR PRODUCING PHARMACEUTICAL COMPOSITION PARTICLES
Document Type and Number:
WIPO Patent Application WO/2019/039420
Kind Code:
A1
Abstract:
Provided are: pharmaceutical composition particles for which both of the masking of the unpleasant taste thereof and the improvement in the elution properties thereof can be achieved; orally disintegrating tablets each containing the pharmaceutical composition particles; and a method for producing pharmaceutical composition particles. Each of the pharmaceutical composition particles comprises a core particle containing a drug and a water-soluble gelatinizable/swellable substance and an outer layer that contains a water-insoluble substance and coats the outside of the core particle. The method for producing pharmaceutical composition particles according to the present invention comprises: a pulverization step of pulverizing a water-soluble gelatinizable/swellable substance so that the pulverized product can have an average particle diameter of 15 μm or less; a core particle production step of mixing the gelatinizable/swellable substance pulverized in the pulverization step with a drug to produce core particles; and outer layer formation step of coating the outside of each of the core particles with a water-insoluble substance to form an outer layer.

Inventors:
HAYASHIDA TOMOHIRO (JP)
HOASHI YOHEI (JP)
IJITSU SHIN (JP)
NAKANO YOSHIO (JP)
YAMAZAKI JUNJI (JP)
INOUE KATSUHISA (JP)
AIZAWA ATSUSHI (JP)
Application Number:
PCT/JP2018/030618
Publication Date:
February 28, 2019
Filing Date:
August 20, 2018
Export Citation:
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Assignee:
NIPRO CORP (JP)
ZENSEI PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K9/20
Domestic Patent References:
WO2014181390A12014-11-13
WO2005039542A12005-05-06
WO2017146053A12017-08-31
WO2017146052A12017-08-31
WO2002096392A12002-12-05
WO2012036078A12012-03-22
Foreign References:
JP2004231520A2004-08-19
JP2002212062A2002-07-31
JP2010532384A2010-10-07
JP2007063263A2007-03-15
JP2008214334A2008-09-18
JP2008260712A2008-10-30
JP2011063627A2011-03-31
JP2000191519A2000-07-11
JP2011225468A2011-11-10
JPH03130214A1991-06-04
JP2007532623A2007-11-15
JP2012240917A2012-12-10
JP4019374B22007-12-12
JP3746167B22006-02-15
Other References:
See also references of EP 3673901A4
Attorney, Agent or Firm:
AKAOKA Kazuo et al. (JP)
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