Title:
PHARMACEUTICAL COMPOSITION, PATCH AND MANUFACTURING METHOD THEREOF, ANALGESIC METHOD, AND APPLICATION
Document Type and Number:
WIPO Patent Application WO/2019/141178
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition, a patch and a manufacturing method thereof, an analgesic method, and an application. The pharmaceutical composition comprises a single anesthetic active ingredient. The anesthetic active ingredient comprises a water-dissolving anesthetic active ingredient and an anesthetic active ingredient existing in an insoluble form. The mass percent content of the anesthetic active ingredient in the pharmaceutical composition is 2% or more. The mass percent content of the water-dissolving anesthetic active ingredient in the pharmaceutical composition is 1% or less. The anesthetic active ingredient comprises lidocaine, tetracaine, bupivacaine, articaine, cinchocaine, dibucaine, etidocaine, levobupivacaine, mepivacaine, prilocaine, ropivacaine, trimecaine, benzocaine or procaine. The pharmaceutical composition and the patch can provide continuous analgesia for 12-30 hours. The patch is resistant to a certain amount of external squeezing force, preventing a formulation layer covered by the same from being squeezed out, thereby maintaining the thickness of the formulation layer.
Inventors:
ZHANG JIE (CN)
Application Number:
PCT/CN2019/071898
Publication Date:
July 25, 2019
Filing Date:
January 16, 2019
Export Citation:
Assignee:
ZHANG JIE (CN)
International Classes:
A61K31/167; A61K31/245; A61K31/445; A61K45/00; A61K47/32; A61P23/02
Foreign References:
| CN101966170A | 2011-02-09 | |||
| JP2002193795A | 2002-07-10 | |||
| CN103608009A | 2014-02-26 | |||
| CN101861148A | 2010-10-13 | |||
| CN1193909A | 1998-09-23 | |||
| CN201810045015A | 2018-01-17 |
Other References:
See also references of EP 3741364A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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