Title:
PHARMACEUTICAL COMPOSITION FOR PERITONEAL DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/153507
Kind Code:
A1
Abstract:
Provided are: a novel pharmaceutical composition for peritoneal disorders or peritoneal fibrosis accompanied by peritoneal inflammation; and a novel peritoneal dialysis fluid. The present invention provides a pharmaceutical composition for peritoneal disorders accompanied by peritoneal inflammation, the composition containing, for example, a peptide compound represented by a general formula (I) (SEQ ID NO:1) as an active ingredient. (In the formula, [Mod] represents a modifying group, [Lin] represents a linking group, and [Pep] represents a peptide chain having an amino acid sequence comprising one amino acid residue or 2-15 amino acid residues. t, s, and m each independently represent 0 or 1. Xa1 represents Val etc., Xa2 represents Gln etc., Xa3 represents Phe etc., Xa4 represents Gly etc., Xa5 represents Val etc., Xa6 represents Arg etc., Xa7 represents Ser etc., and Xa8 represents Tyr etc. Bq represents -SH HS- or -S-S-.)
Inventors:
KITAMURA KAZUO (JP)
MIZUNO MASASHI (JP)
KIM HONGSOO (JP)
MIZUNO MASASHI (JP)
KIM HONGSOO (JP)
Application Number:
PCT/JP2023/004731
Publication Date:
August 17, 2023
Filing Date:
February 13, 2023
Export Citation:
Assignee:
UNIV MIYAZAKI (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
NATIONAL UNIV CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP)
International Classes:
A61K47/54; A61K38/00; A61K38/16; A61K47/60; A61K47/62; A61K47/68; A61P43/00; C07K14/00
Domestic Patent References:
| WO2018181638A1 | 2018-10-04 | |||
| WO2022030580A1 | 2022-02-10 | |||
| WO2021201271A1 | 2021-10-07 |
Foreign References:
| JP2000038348A | 2000-02-08 |
Other References:
CLEMENTI GIUSEPPE, CARUSO ANTONINA, MARIA VINCENZA, CUTULI CATENA, PRATO AGATINA, GUIDE MANGANO NUNZIO, AMICO-ROXAS MATILDE: "ANTIINFLAMMATORY ACTIVITY OF ADRENOMEDULLIN IN THE ACETIC ACID PERITONITIS IN RATS", LIFE SCIENCES, vol. 65, no. 15, 3 September 1999 (1999-09-03), pages PL - PL-208, XP093083873, DOI: 10.1016/S0024-3205(99)00406-3
KUROISHI NOBUKO, NAGATA SAYAKA, AKASHI EMIKO, ASHIZUKA SHINYA, KATO JOHJI, YAMASAKI MOTOO, KITAMURA KAZUO: "Development of a novel human adrenomedullin derivative: human serum albumin-conjugated adrenomedullin", JOURNAL OF BIOCHEMISTRY, OXFORD UNIVERSITY PRESS, GB, vol. 170, no. 4, 4 December 2021 (2021-12-04), GB , pages 445 - 451, XP055895503, ISSN: 0021-924X, DOI: 10.1093/jb/mvab057
KUROISHI NOBUKO, NAGATA SAYAKA, AKASHI EMIKO, ASHIZUKA SHINYA, KATO JOHJI, YAMASAKI MOTOO, KITAMURA KAZUO: "Development of a novel human adrenomedullin derivative: human serum albumin-conjugated adrenomedullin", JOURNAL OF BIOCHEMISTRY, OXFORD UNIVERSITY PRESS, GB, vol. 170, no. 4, 4 December 2021 (2021-12-04), GB , pages 445 - 451, XP055895503, ISSN: 0021-924X, DOI: 10.1093/jb/mvab057
Attorney, Agent or Firm:
SHIMIZU Naoto et al. (JP)
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