FLUPENTIXOL/MELITRACEN PHARMACEUTICAL COMPOSITION AND PREPARATION THEREOF

WIPO Patent Application WO/2020/143394

A1

A flupentixol/melitracen pharmaceutical composition and a preparation thereof, in the technical field of pharmaceutical preparations. The flupentixol/melitracen pharmaceutical composition includes flupentixol dihydrochloride, melitracen hydrochloride and an antioxidant. By means of adding an antioxidant, it is possible to effectively strengthen stability of the flupentixol/melitracen compound preparation, and it is possible to effectively control contaminants such as Lu28-159 and trifluoromethylthioxanthenone produced by flupentixol degradation, decreasing contaminant levels and ensuring safety and efficacy of the product; compared with the original tablet Deanxit, the present invention has similar in vitro dissolution behavior and bioequivalence.

WO/2012/005340	TABLET CONTAINING FERRIC CITRATE
JP2012519156	(4AR, 10AR) -1-N-propyl-1,2,3,4,5,10,10A-octahydrobenzo [G] quinoline-6,7-diol and related compounds on the oral mucosa, nasal mucosa or Method of administration through the skin and its pharmaceutical composition
JPH07116050	[Title of the Invention] An oral administration agent containing Hibiki Flute Maru Extract

BU SHUI (CN)
CHEN YUNWAN (CN)
YANG YUDONG (CN)
HU GONGYUN (CN)
WANG DUANTONG (CN)
ZHENG WEIGUO (CN)
XU LIGUI (CN)

PCT/CN2019/125211

July 16, 2020

December 13, 2019

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GUANGDONG SCIENTIFIC FINDER PHARMACEUTICAL TECH CO LTD (CN)
HAINAN HUINENG PHARMACEUTICAL CO LTD (CN)

A61K9/20; A61K9/28

CN109674754A	2019-04-26
CN109771386A	2019-05-21
CN108362792A	2018-08-03
CN104288153A	2015-01-21
CN105663062A	2016-06-15
CN108498470A	2018-09-07
EP2374450A1	2011-10-12

SCIHEAD IP LAW FIRM (CN)

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