PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, CONTAINING 2,6-DICHLORO-4-(4-(4-HYDROXYCYCLOHEXYLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)PHENOL AS ACTIVE INGREDIENT

Title:

PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, CONTAINING 2,6-DICHLORO-4-(4-(4-HYDROXYCYCLOHEXYLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)PHENOL AS ACTIVE INGREDIENT

Document Type and Number:

WIPO Patent Application WO/2022/235054

Kind Code:

A1

Abstract:

The present invention relates to a pharmaceutical composition for preventing or treating cancer, containing 2,6-dichloro-4-(4-(4-hydroxycyclohexylamino)-7H-pyrrolo[2,3-D]pyrimidin-5-yl)phenol as an active ingredient. It has been ascertained that the present invention inhibits the formation of mammospheres in a breast cancer cell line and, when compared to anticancer drugs sorafenib and etoposide, which are topoisomerase inhibitors widely used in lung cancer, ovarian cancer, colon cancer, melanoma and the like, exhibits remarkable effects greater than or equal to those of the anticancer drugs sorafenib and etoposide. In addition, a compound of example 1, according to the present invention, exhibits synergistic anticancer effects when combined with radiotherapy or other anticancer drugs in a breast cancer cell line and a liver cancer cell line, and thus can be developed as an anticancer drug or a food exhibiting excellent effects in the treatment of cancer.

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Inventors:

JANG BONG KEUN (KR)

Application Number:

PCT/KR2022/006339

Publication Date:

November 10, 2022

Filing Date:

May 03, 2022

Export Citation:

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Assignee:

JBKLAB CO LTD (KR)

International Classes:

A61K31/519; A23L33/10; A61P35/00

Domestic Patent References:

WO1998007726A1

1998-02-26

Foreign References:

KR20200012168A	2020-02-05
KR20150108389A	2015-09-25
US20080194557A1	2008-08-14

Other References:

TIAGO ELIAS HEINEN, SANTOS RAFAEL PEREIRA DOS, DA ROCHA AMANDA, SANTOS MICHEL PINHEIRO DO, LOPEZ PATRíCIA LUCIANA DA COSTA, F: "Trk inhibition reduces cell proliferation and potentiates the effects of chemotherapeutic agents in Ewing sarcoma", ONCOTARGET, vol. 7, no. 23, 7 June 2016 (2016-06-07), pages 34860 - 34880, XP055615967, DOI: 10.18632/oncotarget.8992
REV PERU MED EXP SALUD PUBLICA., vol. 30, no. 4, December 2013 (2013-12-01), pages 649 - 56

Attorney, Agent or Firm:

LEE, Won Hee (KR)

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