Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING INHIBITOR OF PLRG1 (PLEIOTROPIC REGULATOR 1) AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/061828
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer comprising an inhibitor of PLRG1 (pleiotropic regulator 1) as an active ingredient, a method for treating cancer comprising a step of administering the composition to an individual, a composition for diagnosing cancer comprising an agent for measuring an expression level of PLRG1, and a method for providing information for diagnosing cancer comprising a step of measuring an expression level of PLRG1, and a method for screening an agent for preventing or treating cancer. PLRG1 (pleiotropic regulator 1) is overexpressed in cancer cells, and when an expression of PLRG1 is inhibited, a cancer cell-specific cell death can be induced. Thus, the inhibitor of PLRG1 of the present invention has an excellent effect as an anticancer agent without side effects, and also can be used to diagnose cancer and screen anticancer agents by measuring an expression level of PLRG1.
Inventors:
LEE KEE-HO (KR)
KIM SUNGSUB (KR)
KIM YEON-SOO (KR)
PARK EUN-RAN (KR)
SHIN HYUN JIN (KR)
LEE EUN-JU (KR)
HAM YONG-HO (KR)
KIM SANG BUM (KR)
PARK SUN-HOO (KR)
HAN CHUL-JU (KR)
HONG SUNG HEE (KR)
KIM YANG HYUN (KR)
KIM JUNG MIN (KR)
KIM MI YEUN (KR)
KANG MOONKYOUNG (KR)
SONG EUN YEONG (KR)
KIM SUNGSUB (KR)
KIM YEON-SOO (KR)
PARK EUN-RAN (KR)
SHIN HYUN JIN (KR)
LEE EUN-JU (KR)
HAM YONG-HO (KR)
KIM SANG BUM (KR)
PARK SUN-HOO (KR)
HAN CHUL-JU (KR)
HONG SUNG HEE (KR)
KIM YANG HYUN (KR)
KIM JUNG MIN (KR)
KIM MI YEUN (KR)
KANG MOONKYOUNG (KR)
SONG EUN YEONG (KR)
Application Number:
PCT/KR2016/011272
Publication Date:
April 13, 2017
Filing Date:
October 07, 2016
Export Citation:
Assignee:
KOREA INST RADIOLOGICAL & MEDICAL SCIENCES (KR)
International Classes:
A61K39/395; A61K48/00
Foreign References:
| CN1328026A | 2001-12-26 | |||
| CN1333240A | 2002-01-30 | |||
| US20040253646A1 | 2004-12-16 | |||
| KR20100018237A | 2010-02-17 |
Other References:
KLEINRIDDERS, A. ET AL.: "PLRG1 Is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis", MOLECULAR AND CELLULAR BIOLOGY, vol. 29, no. 11, 2009, pages 3173 - 3185, XP055373922
Attorney, Agent or Firm:
SON, Min (KR)
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