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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING, AS ACTIVE INGREDIENT, CALCIUM CHANNEL INHIBITOR OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/147089
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition for preventing or treating cancer, comprising, as an active ingredient, a calcium channel inhibitor or a pharmaceutically acceptable salt thereof. The pharmaceutical composition not only exhibits an excellent effect of inhibiting growth and proliferation of cancer stem cells even when used alone but also exhibits a more excellent pharmacological effect when administering the pharmaceutical composition together with conventional anticancer drugs. Since it is possible to inhibit the recurrence, metastasis, and progression of cancer, the pharmaceutical composition can usefully be used as a pharmaceutical composition or a combined formulation for the prevention or treatment of cancer.

Inventors:
MIN SANG HYUN (KR)
KIM JUN WOO (KR)
LEE HEEJIN (KR)
YU JI HOON (KR)
CHOI DONG KYU (KR)
SONG YOUNGWOO (KR)
CHOI JAEHEON (KR)
KIM JAE HO (KR)
Application Number:
PCT/KR2019/001143
Publication Date:
August 01, 2019
Filing Date:
January 28, 2019
Export Citation:
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Assignee:
DAEGU GYEONGBUK MEDICAL INNOVATION FOUND (KR)
NAT UNIV PUSAN IND UNIV COOP FOUND (KR)
International Classes:
A61K31/4545; A23L33/10; A61K31/4422; A61K31/496; A61K45/06; A61P35/00
Domestic Patent References:
WO2015157471A12015-10-15
WO2007008499A12007-01-18
WO2019008516A22019-01-10
Foreign References:
KR20160124012A2016-10-26
Other References:
SHIRAKI, N. ET AL.: "Increase in doxorubicin cytotoxicity by inhibition of P-glycoprotein activity with lomerizine", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 24, no. 5, 2001, pages 555 - 557, XP055628797
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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