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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING NAPHTHOQUINONE-BASED COMPOUND AND IMMUNE CHECKPOINT INHIBITOR AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2022/010322
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for preventing or treating cancer, comprising: a naphthoquinone-based compound; and at least one selected from an immune checkpoint inhibitor and an immunogenic apoptosis inducer, as active ingredients, and exhibiting a significantly higher anticancer effect than in a case where each medication is administered alone. Accordingly, a synergistic anticancer effect of inhibiting the growth and metastasis of cancer cells can be expected in cancer cells in which anticancer effects were insignificant when conventional anticancer drugs were administered alone. Therefore, the composition comprising the naphthoquinone-based compound can be usefully used as a drug for preventing or treating cancer together with the immune checkpoint inhibitor and/or the immunogenic apoptosis inducer.

Inventors:
SO HONG SEOB (KR)
KWAK TAE HWAN (KR)
KIM HYUNG JIN (KR)
Application Number:
PCT/KR2021/008830
Publication Date:
January 13, 2022
Filing Date:
July 09, 2021
Export Citation:
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Assignee:
NADIANBIO LTD (KR)
International Classes:
A61K31/343; A61K45/06; A61P35/00
Domestic Patent References:
WO2018213631A12018-11-22
WO2006088315A12006-08-24
WO2006020719A22006-02-23
Foreign References:
KR20190137911A2019-12-11
JP2009538298A2009-11-05
KR20190025646A2019-03-11
KR20190088428A2019-07-26
KR20050089007A2005-09-07
US20200216473A12020-07-09
KR20200055116A2020-05-20
US5969163A1999-10-19
KR101739361B12017-05-25
KR101739361B12017-05-25
KR101644778B12016-08-16
KR102247694B12021-05-03
US9066922B22015-06-30
Other References:
KROEMER ET AL., ANNU. REV. IMMUNOL., vol. 31, 2013, pages 51 - 72
PANDIT ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 467, 2015, pages 697 - 703
SHEN ET AL., SCI REP, vol. 7, 2017, pages 3006
See also references of EP 4180034A4
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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