Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING CARNITINE ACYLCARNITINE CARRIER INHIBITOR AND CARNITINE OCTANOYLTRANSFERASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/048511
Kind Code:
A1
Abstract:
The present invention relates to: a pharmaceutical composition for preventing or treating cancer, comprising a carnitine acylcarnitine carrier (CAC) inhibitor and a carnitine octanoyltransferase (COT) inhibitor; and an anticancer adjuvant. The composition of the present invention significantly reduces cancer cell growth compared to when the CAC inhibitor or the COT inhibitor is used alone, and thus can be provided as an effective anticancer agent for combined use.
Inventors:
KIM SOO YOUL (KR)
Application Number:
PCT/KR2022/014285
Publication Date:
March 30, 2023
Filing Date:
September 23, 2022
Export Citation:
Assignee:
NAT CANCER CT (KR)
NEW CANCER CURE BIO CO LTD (KR)
NEW CANCER CURE BIO CO LTD (KR)
International Classes:
A61K31/4439; A61K31/5415; A61K45/06; A61P35/00
Foreign References:
| KR20200041806A | 2020-04-22 |
Other References:
KAMGAR-DAYHOFF PAREESA, BRELIDZE TINATIN I.: "Multifaceted effect of chlorpromazine in cancer: implications for cancer treatment", ONCOTARGET, vol. 12, no. 14, 6 July 2021 (2021-07-06), pages 1406 - 1426, XP093050764, DOI: 10.18632/oncotarget.28010
MOTOHASHI NOBORU, KAWASE MASAMI, SATOH KAZUE, SAKAGAMI HIROSHI: "Cytotoxic Potential of Phenothiazines", CURRENT DRUG TARGETS, BENTHAM SCIENCE PUBLISHER,, US, vol. 7, no. 9, 1 September 2006 (2006-09-01), US , pages 1055 - 1066, XP093054032, ISSN: 1389-4501, DOI: 10.2174/138945006778226624
YANG CHANG-EN, LEE WEN-YING, CHENG HUNG-WEI, CHUNG CHU-HUNG, MI FU-LOWNG, LIN CHENG-WEI: "The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells", CHEMICO-BIOLOGICAL INTERACTIONS., ELSEVIER SCIENCE IRLAND., IR, vol. 302, 1 April 2019 (2019-04-01), IR , pages 28 - 35, XP093054037, ISSN: 0009-2797, DOI: 10.1016/j.cbi.2019.01.033
JUN‐SHENG WANG; HAO‐JIE ZHU; JOHN S. MARKOWITZ; JENNIFER L. DONOVAN; HONG‐JIE YUAN; C. LINDSAY DEVANE: "Antipsychotic Drugs Inhibit the Function of Breast Cancer Resistance Protein", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, NORDIC PHARMACOLOGICAL SOCIETY, COPENHAGEN, DK, vol. 103, no. 4, 16 September 2008 (2008-09-16), COPENHAGEN, DK , pages 336 - 341, XP072369327, ISSN: 1742-7835, DOI: 10.1111/j.1742-7843.2008.00298.x
MOTOHASHI NOBORU, KAWASE MASAMI, SATOH KAZUE, SAKAGAMI HIROSHI: "Cytotoxic Potential of Phenothiazines", CURRENT DRUG TARGETS, BENTHAM SCIENCE PUBLISHER,, US, vol. 7, no. 9, 1 September 2006 (2006-09-01), US , pages 1055 - 1066, XP093054032, ISSN: 1389-4501, DOI: 10.2174/138945006778226624
YANG CHANG-EN, LEE WEN-YING, CHENG HUNG-WEI, CHUNG CHU-HUNG, MI FU-LOWNG, LIN CHENG-WEI: "The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells", CHEMICO-BIOLOGICAL INTERACTIONS., ELSEVIER SCIENCE IRLAND., IR, vol. 302, 1 April 2019 (2019-04-01), IR , pages 28 - 35, XP093054037, ISSN: 0009-2797, DOI: 10.1016/j.cbi.2019.01.033
JUN‐SHENG WANG; HAO‐JIE ZHU; JOHN S. MARKOWITZ; JENNIFER L. DONOVAN; HONG‐JIE YUAN; C. LINDSAY DEVANE: "Antipsychotic Drugs Inhibit the Function of Breast Cancer Resistance Protein", BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, NORDIC PHARMACOLOGICAL SOCIETY, COPENHAGEN, DK, vol. 103, no. 4, 16 September 2008 (2008-09-16), COPENHAGEN, DK , pages 336 - 341, XP072369327, ISSN: 1742-7835, DOI: 10.1111/j.1742-7843.2008.00298.x
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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