Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER, COMPRISING CARNITINE ACYLCARNITINE CARRIER INHIBITOR AND PEROXISOMAL BETA OXIDATION INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/128464
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising a carnitine acylcarnitine carrier (CAC) inhibitor and a peroxisomal beta oxidation inhibitor. In the present invention, it has been identified that co-administration of a carnitine acylcarnitine carrier inhibitor and a peroxisomal beta oxidation inhibitor reduces the growth of cancer cells significantly better than when each drug is used alone, and that there are anti-cancer synergistic effects resulting from co-administration. Therefore, the composition comprising a carnitine acylcarnitine carrier inhibitor and a peroxisomal beta oxidation inhibitor, of the present invention, can be provided as an effective anti-cancer agent for combination therapy.
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Inventors:
KIM SOO YOUL (KR)
Application Number:
PCT/KR2022/021020
Publication Date:
July 06, 2023
Filing Date:
December 22, 2022
Export Citation:
Assignee:
NEW CANCER CURE BIO CO LTD (KR)
International Classes:
A61K31/4439; A61K31/4458; A61K31/495; A61K31/5415; A61K45/06; A61P35/00
Foreign References:
| KR20200041806A | 2020-04-22 | |||
| KR101538264B1 | 2015-07-20 | |||
| KR102315103B1 | 2021-10-20 |
Other References:
TONAZZI ANNAMARIA, EBERINI IVANO, INDIVERI CESARE: "Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics", PLOS ONE, vol. 8, no. 12, pages e82286, XP093076553, DOI: 10.1371/journal.pone.0082286
MU JIASHENG, XU HAINENG, YANG YU, HUANG WEIDAN, XIAO JING, LI MAOLAN, TAN ZHUJUN, DING QICHEN, ZHANG LIN, LU JIANHUA, WU XIANGSONG: "Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer", ONCOLOGY REPORTS, SPANDIDOS PUBL., vol. 31, no. 5, 1 May 2014 (2014-05-01), pages 2107 - 2114, XP093076558, ISSN: 1021-335X, DOI: 10.3892/or.2014.3068
MU JIASHENG, XU HAINENG, YANG YU, HUANG WEIDAN, XIAO JING, LI MAOLAN, TAN ZHUJUN, DING QICHEN, ZHANG LIN, LU JIANHUA, WU XIANGSONG: "Thioridazine, an antipsychotic drug, elicits potent antitumor effects in gastric cancer", ONCOLOGY REPORTS, SPANDIDOS PUBL., vol. 31, no. 5, 1 May 2014 (2014-05-01), pages 2107 - 2114, XP093076558, ISSN: 1021-335X, DOI: 10.3892/or.2014.3068
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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