Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CAUSED BY OVEREXPRESSION OF Β-CATENIN, COMPRISING NEURL GENE, EXPRESSION VECTOR COMPRISING SAME, OR NEURL PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/243759
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer caused by overexpression of β-catenin, comprising an expression vector comprising a NEURL gene or a NEURL protein as an active ingredient, wherein NEURL has excellent effect in inhibiting tumor cells and inhibiting the Wnt/β-catenin signaling pathway through β-catenin degradation and inhibition of mRNA expression of c-Myc, survivin, and cyclin D1, and the pharmaceutical composition is thus highly effective in treating cancer caused by overexpression of β-catenin such as colorectal cancer, stomach cancer, breast cancer, and prostate cancer.
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Inventors:
YI JOO MI (KR)
Application Number:
PCT/KR2022/010495
Publication Date:
December 21, 2023
Filing Date:
July 19, 2022
Export Citation:
Assignee:
UNIV INJE IND ACAD COOP FOUND (KR)
International Classes:
A61K48/00; A61K38/17; A61P35/00; C12Q1/6886; G01N33/574; G01N33/68
Foreign References:
| KR20180066237A | 2018-06-18 | |||
| KR20200011933A | 2020-02-04 | |||
| KR20180106681A | 2018-10-01 | |||
| KR20210145922A | 2021-12-03 | |||
| KR20150014600A | 2015-02-09 |
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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