Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CHOLESTATIC LIVER DISEASE, CONTAINING ΒETA-LAPACHONE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2022/075756
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cholestatic liver disease, containing β-lapachone as an active ingredient, and can provide an agent for effectively preventing and treating cholestatic liver disease.
Inventors:
YOON JOO SEOG (KR)
SEO KANG SIK (KR)
HAN JEONG SU (KR)
MOON SUNG JE (KR)
LEE JUNG HOON (KR)
YOON SOO BIN (KR)
SEO KANG SIK (KR)
HAN JEONG SU (KR)
MOON SUNG JE (KR)
LEE JUNG HOON (KR)
YOON SOO BIN (KR)
Application Number:
PCT/KR2021/013732
Publication Date:
April 14, 2022
Filing Date:
October 06, 2021
Export Citation:
Assignee:
CUROME BIOSCIENCES CO LTD (KR)
International Classes:
A61K31/353; A23L33/105; A23L33/135; A61K31/575; A61K35/745; A61K35/747; A61P1/16
Foreign References:
| KR20190026687A | 2019-03-13 | |||
| KR20060092106A | 2006-08-22 |
Other References:
SHIN SANGHEE, PARK JISOO, LI YUWEN, MIN KI NAM, KONG GYEYEONG, HUR GANG MIN, KIM JIN MAN, SHONG MINHO, JUNG MIN-SUK, PARK JONG KOO: "β-Lapachone alleviates alcoholic fatty liver disease in rats", CELLULAR SIGNALLING., ELSEVIER SCIENCE LTD., GB, vol. 26, no. 2, 1 February 2014 (2014-02-01), GB , pages 295 - 305, XP055919322, ISSN: 0898-6568, DOI: 10.1016/j.cellsig.2013.11.020
ZHAO QI, YANG RUI, WANG JING, HU DAN-DAN, LI FEI: "PPARα activation protects against cholestatic liver injury", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055919323, DOI: 10.1038/s41598-017-10524-6
WANG PING, KOYAMA YUKINORI, LIU XIAO, XU JUN, MA HSIAO-YEN, LIANG SHUANG, KIM IN H., BRENNER DAVID A., KISSELEVA TATIANA: "Promising Therapy Candidates for Liver Fibrosis", FRONTIERS IN PHYSIOLOGY, vol. 7, XP055919334, DOI: 10.3389/fphys.2016.00047
See also references of EP 4023220A4
ZHAO QI, YANG RUI, WANG JING, HU DAN-DAN, LI FEI: "PPARα activation protects against cholestatic liver injury", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055919323, DOI: 10.1038/s41598-017-10524-6
WANG PING, KOYAMA YUKINORI, LIU XIAO, XU JUN, MA HSIAO-YEN, LIANG SHUANG, KIM IN H., BRENNER DAVID A., KISSELEVA TATIANA: "Promising Therapy Candidates for Liver Fibrosis", FRONTIERS IN PHYSIOLOGY, vol. 7, XP055919334, DOI: 10.3389/fphys.2016.00047
See also references of EP 4023220A4
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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