Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CONTRAST MEDIA-INDUCED NEPHROTOXICITY
Document Type and Number:
WIPO Patent Application WO/2022/030665
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating contrast media-induced nephrotoxicity. More particularly, a pharmaceutical composition containing paricalcitol prevents renal dysfunction by controlling mitophagy and aging, and reduces tissue damage, thereby exhibiting a preventive or therapeutic effect on contrast media-induced nephrotoxicity.
Inventors:
BAE EUN JIN (KR)
KIM JIN HYUN (KR)
PARK DONG JUN (KR)
KIM JIN HYUN (KR)
PARK DONG JUN (KR)
Application Number:
PCT/KR2020/010337
Publication Date:
February 10, 2022
Filing Date:
August 05, 2020
Export Citation:
Assignee:
GYEONGSANG NATIONAL UNIV HOSPITAL (KR)
International Classes:
A61K31/047; A61K49/04; A61P39/02
Foreign References:
| KR20160113664A | 2016-09-30 |
Other References:
SAHIN I, ÖZKAYNAK B, SAR M, BITER H I, MERT B, OKUYAN E, KAYALAR N, CAN M M, GÜNGÖR B, ERENTUG V, DINÇKAL M H: "Paricalcitol counteracts the increased contrast induced nephropathy caused by renin-angiotensin-aldosterone system blockade therapy in a rat model", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, VERDUCI EDITORE, IT, vol. 18, 1 January 2014 (2014-01-01), IT , XP055893952, ISSN: 1128-3602
MICHELE ANDREUCCI, TERESA FAGA, GIOVANBATTISTA DE SARRO, ASHOUR MICHAEL: "The toxicity of Iodinated Radiographic Contrast Agents in the clinical practice", JOURNAL OF NEPHROLOGY ADVANCES, vol. 1, no. 1, pages 6 - 41, XP055893960, DOI: 10.14302/issn.2574-4488.jna-14-601
ARI E, KEDRAH A E, ALAHDAB Y, BULUT G, EREN Z, BAYTEKIN O, ODABASI D: "Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model", BRITISH JOURNAL OF RADIOLOGY., BRITISH INSTITUTE OF RADIOLOGY, LONDON., GB, vol. 85, no. 1016, 1 August 2012 (2012-08-01), GB , pages 1038 - 1043, XP055893965, ISSN: 0007-1285, DOI: 10.1259/bjr/16327485
PARK JEONG WOO ET AL: "Paricalcitol attenuates cyclosporine-induced kidney injury in rats", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 77, no. 12, 1 June 2010 (2010-06-01), GB , pages 1076 - 1085, XP002770143, ISSN: 0085-2538, DOI: 10.1038/ki.2010.69
MICHELE ANDREUCCI, TERESA FAGA, GIOVANBATTISTA DE SARRO, ASHOUR MICHAEL: "The toxicity of Iodinated Radiographic Contrast Agents in the clinical practice", JOURNAL OF NEPHROLOGY ADVANCES, vol. 1, no. 1, pages 6 - 41, XP055893960, DOI: 10.14302/issn.2574-4488.jna-14-601
ARI E, KEDRAH A E, ALAHDAB Y, BULUT G, EREN Z, BAYTEKIN O, ODABASI D: "Antioxidant and renoprotective effects of paricalcitol on experimental contrast-induced nephropathy model", BRITISH JOURNAL OF RADIOLOGY., BRITISH INSTITUTE OF RADIOLOGY, LONDON., GB, vol. 85, no. 1016, 1 August 2012 (2012-08-01), GB , pages 1038 - 1043, XP055893965, ISSN: 0007-1285, DOI: 10.1259/bjr/16327485
PARK JEONG WOO ET AL: "Paricalcitol attenuates cyclosporine-induced kidney injury in rats", KIDNEY INTERNATIONAL, NATURE PUBLISHING GROUP, LONDON, GB, vol. 77, no. 12, 1 June 2010 (2010-06-01), GB , pages 1076 - 1085, XP002770143, ISSN: 0085-2538, DOI: 10.1038/ki.2010.69
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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