Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DEGENERATIVE BRAIN DISEASE COMPRISING NATURAL KILLER CELL
Document Type and Number:
WIPO Patent Application WO/2023/182801
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing and treating a degenerative brain disease, specifically dementia, comprising an activated natural killer cell as an active ingredient. The pharmaceutical composition comprising a mouse-derived activated natural killer cell as an active ingredient, according to the present invention, regulates the activity of microglial cells and inhibits the deposition of amyloid β plaques. In addition, the pharmaceutical composition showed an excellent effect on cognitive function improvement in an animal model of dementia. Furthermore, when a human peripheral blood mononuclear cell-derived natural killer cell and a human induced pluripotent stem cell-derived natural killer cell were activated, it was confirmed that the expression of some genes involved in restoring the activity of microglial cells was similar to or higher than that of a mouse-derived activated natural killer cell. Therefore, the pharmaceutical composition of the present invention can be effectively used for preventing or treating a degenerative brain disease, such as dementia, Parkinson's disease, and Huntington's disease, and improving cognitive impairment.
Inventors:
HWANG DO WON (KR)
KI YOUNG WOOK (KR)
KI YOUNG WOOK (KR)
Application Number:
PCT/KR2023/003782
Publication Date:
September 28, 2023
Filing Date:
March 22, 2023
Export Citation:
Assignee:
THERABEST CO LTD (KR)
International Classes:
A61K35/17; A61K38/19; A61K38/21; A61P25/28; C12N5/0783
Domestic Patent References:
| WO2020172328A1 | 2020-08-27 |
Foreign References:
| KR20200004758A | 2020-01-14 | |||
| KR20110112308A | 2011-10-12 | |||
| KR101191305B1 | 2012-10-16 | |||
| KR20130020949A | 2013-03-04 |
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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