Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING GERIATRIC DISEASES COMPRISING NEURAL STEM CELLS DERIVED FROM THREE-DIMENSIONAL HYPOTHALAMUS ORGANOID AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/224431
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising, as an active ingredient, hypothalamus-like organoid-derived neural stem cells for preventing and treating geriatric diseases. It was found that decreased memory, cognitive ability, muscle strength, muscle tissue density, and bone density in aging mice due to aging were restored when the hypothalamus-like organoid-derived neural stem cells according to the present invention were transplanted into the aging mice. In addition, the transplantation of the hypothalamus-like organoid-derived neural stem cells was found to improve obesity by increasing energy metabolism. It was found that decreased memory, cognitive ability, and muscle strength in aging mice were similarly restored when exosomes isolated from the hypothalamus-like organoid-derived neural stem cells were transplanted into the aging mice. Therefore, the hypothalamus-like organoid-derived neural stem cells according to the present invention are expected to be very useful as an agent for preventing and treating geriatric diseases.
Inventors:
KIM KYUNG SUK (KR)
LEE TAE YONG (KR)
KIM MIN SUNG (KR)
LEE SANG-HUN (KR)
SULISTIO YANUAR ALAN (KR)
KIM MIN SOO (KR)
LEE TAE YONG (KR)
KIM MIN SUNG (KR)
LEE SANG-HUN (KR)
SULISTIO YANUAR ALAN (KR)
KIM MIN SOO (KR)
Application Number:
PCT/KR2023/006861
Publication Date:
November 23, 2023
Filing Date:
May 19, 2023
Export Citation:
Assignee:
CORESTEMCHEMON INC (KR)
International Classes:
A61K35/30; A61P19/10; A61P21/00; A61P25/28; A61P43/00; C12N5/0797
Foreign References:
| KR20210106966A | 2021-08-31 | |||
| CN112011512A | 2020-12-01 | |||
| KR20070032311A | 2007-03-21 |
Other References:
ZHANG YALIN, KIM MIN SOO, JIA BAOSEN, YAN JINGQI, ZUNIGA-HERTZ JUAN PABLO, HAN CHENG, CAI DONGSHENG: "Hypothalamic stem cells control ageing speed partly through exosomal miRNAs", NATURE, vol. 548, no. 7665, 3 August 2017 (2017-08-03), pages 52 - 57, XP055864173, DOI: 10.1038/nature23282
QIAN XUYU; NGUYEN HA NAM; SONG MINGX M.; HADIONO CHRISTOPHER; OGDEN SARAH C.; HAMMACK CHRISTY; YAO BING; HAMERSKY GREGORY R.; JACO: "Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure", CELL, ELSEVIER, AMSTERDAM NL, vol. 165, no. 5, 22 April 2016 (2016-04-22), Amsterdam NL , pages 1238 - 1254, XP029552288, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.04.032
QIAN XUYU; NGUYEN HA NAM; SONG MINGX M.; HADIONO CHRISTOPHER; OGDEN SARAH C.; HAMMACK CHRISTY; YAO BING; HAMERSKY GREGORY R.; JACO: "Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure", CELL, ELSEVIER, AMSTERDAM NL, vol. 165, no. 5, 22 April 2016 (2016-04-22), Amsterdam NL , pages 1238 - 1254, XP029552288, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.04.032
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
Download PDF: