Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO/2011/096642
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical composition for preventing and treating inflammatory diseases, containing 2-[2-chloro-6-(3-iodobenzyl)-furyn-9-yl]-tetrahydro-thiophene-3,4-diol (LJ-1888) or a pharmaceutically acceptable salt thereof as an active ingredient. The pharmaceutical composition according to the present invention has a remarkably low toxicity compared with a known A3 adenosine receptor agonist or antagonist, and is thus useful for preventing and treating inflammatory diseases.
Inventors:
JEONG LAK SHIN (KR)
LEE SANG KOOK (KR)
CHUNG HWA JIN (KR)
LEE HYUK WOO (KR)
LEE SANG KOOK (KR)
CHUNG HWA JIN (KR)
LEE HYUK WOO (KR)
Application Number:
PCT/KR2010/009112
Publication Date:
November 10, 2011
Filing Date:
December 20, 2010
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
JEONG LAK SHIN (KR)
LEE SANG KOOK (KR)
CHUNG HWA JIN (KR)
LEE HYUK WOO (KR)
JEONG LAK SHIN (KR)
LEE SANG KOOK (KR)
CHUNG HWA JIN (KR)
LEE HYUK WOO (KR)
International Classes:
A61K31/52; A61K31/4178; A61P19/02; A61P29/00
Domestic Patent References:
| WO2008108508A1 | 2008-09-12 | |||
| WO2008023362A2 | 2008-02-28 |
Other References:
BOZAROV, ANDREY ET AL.: "Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine", AMERICAN JOURNAL OF PHYSIOLOGY - GASTROINTESTINAL AND LIVER PHYSIOLOGY, vol. 297, 2009, pages G1147 - G1162
MABLEY, JON ET AL.: "The adenosine A3 receptor agonist, N6-(3-iodobenzyl)- adenosine-5'-N-methyluronamide, is protective in two murine models of colitis", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 466, no. 3, 2003, pages 323 - 329
MABLEY, JON ET AL.: "The adenosine A3 receptor agonist, N6-(3-iodobenzyl)- adenosine-5'-N-methyluronamide, is protective in two murine models of colitis", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 466, no. 3, 2003, pages 323 - 329
Attorney, Agent or Firm:
KIM, Yoon-bae (8th Floor Dongduk Building,151-8, Kwanhoon-dong, Jungro-gu, Seoul 110-300, KR)
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Claims: