Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING INOSITOL POLYPHOSPHATE MULTIKINASE INHIBITOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/128429
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases, containing an inositol polyphosphate multikinase inhibitor as an active ingredient. Specifically, IPMK-depleted mice have a higher survival rate for sepsis than wild-type mice, and an increase in mRNA and protein expression of inflammatory cytokines such as IL-1β, IL-6 and TNF-α within tissue is inhibited when endotoxemia is induced, and thus the composition containing an IPMK inhibitor can be useful for treating inflammatory diseases.
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Inventors:
KIM SEYUN (KR)
KIM EUNHA (KR)
BEON JIYOON (KR)
KIM EUNHA (KR)
BEON JIYOON (KR)
Application Number:
PCT/KR2018/000203
Publication Date:
July 12, 2018
Filing Date:
January 04, 2018
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K48/00; A23L33/13; A61K31/713; A61K39/395; G01N33/50
Domestic Patent References:
| WO2014201021A2 | 2014-12-18 |
Foreign References:
| KR0179347B1 | 1999-04-01 |
Other References:
LEE, J. Y. ET AL.: "Inositol Polyphosphate Multikinase Signaling in the Regulation of Metabolism", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1271, no. 1, 2012, pages 68 - 74, XP055512919
MAAG, D. ET AL.: "Inositol Polyphosphate Multikinase Is a Physiologic PI3-kinase that Activates Akt/PKB", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108, no. 4, 25 January 2011 (2011-01-25), pages 1391 - 1396, XP055512923
DAILEY, M. J. ET AL.: "Inositol Polyphosphate Multikinase: An Emerging Player for the Central Action of AMP-activated Protein Kinase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 421, 7 April 2012 (2012-04-07), pages 1 - 3, XP028421334
KIM, E. ET AL.: "Inositol Polyphosphate Multikinase Is a Coactivator for Serum Response Factor-dependent Induction of Immediate Early Genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 49, 3 December 2013 (2013-12-03), pages 19938 - 19943, XP055512928
MAAG, D. ET AL.: "Inositol Polyphosphate Multikinase Is a Physiologic PI3-kinase that Activates Akt/PKB", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 108, no. 4, 25 January 2011 (2011-01-25), pages 1391 - 1396, XP055512923
DAILEY, M. J. ET AL.: "Inositol Polyphosphate Multikinase: An Emerging Player for the Central Action of AMP-activated Protein Kinase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 421, 7 April 2012 (2012-04-07), pages 1 - 3, XP028421334
KIM, E. ET AL.: "Inositol Polyphosphate Multikinase Is a Coactivator for Serum Response Factor-dependent Induction of Immediate Early Genes", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 110, no. 49, 3 December 2013 (2013-12-03), pages 19938 - 19943, XP055512928
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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