Title:
PHARMACEUTICAL COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING OSTEOCALCIN
Document Type and Number:
WIPO Patent Application WO/2020/196953
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for effectively preventing or treating inflammatory diseases. A pharmaceutical composition comprising undercarboxylated osteocalcin according to the present invention can effectively inhibit the production of TNF-α, IL-1β or IL-6 which are inflammatory cytokine, and thus can be utilized in various industry fields such as drugs and foods as a substance for preventing, treating or alleviating various inflammatory diseases.
Inventors:
BAEK KYUNGHWA (KR)
PARK DANBI (KR)
PARK DANBI (KR)
Application Number:
PCT/KR2019/003555
Publication Date:
October 01, 2020
Filing Date:
March 27, 2019
Export Citation:
Assignee:
GENEROATH CO LTD (KR)
International Classes:
A61K38/22; A23L33/17; A61P19/02; A61P29/00
Domestic Patent References:
| WO2008033518A2 | 2008-03-20 |
Foreign References:
| KR20090036237A | 2009-04-14 |
Other References:
HILL, H. S.: "Carboxylated and Uncarboxylated Forms of Osteocalcin Directly Modulate the Glucose Transport System and Inflammation in Adipocytes", HORM. METAB. RES., vol. 46, 2014, pages 341 - 347, XP055613535, DOI: 10.1055/s-0034-1368709
URSZULA RAZNY, DANUTA FEDAK, BEATA KIEC-WILK, JOANNA GORALSKA, ANNA GRUCA, ANNA ZDZIENICKA, MALGORZATA KIEC-KLIMCZAK, BOGDAN SOLNI: "Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes", DIABETES/METABOLISM RESEARCH AND REVIEWS, vol. 33, no. 3, 7 November 2016 (2016-11-07) - March 2017 (2017-03-01), pages e2862, XP055744065
ANISHA A. GUPTE, SABEK OMAIMA M., FRAGA DANIEL, MINZE LAURIE J., NISHIMOTO SATORU K., LIU JOEY Z., AFSHAR SOLMAZ, GABER LILLIAN, L: "Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome", ENDOCRINOLOGY, vol. 155, no. 12, 3 October 2014 (2014-10-03) - December 2014 (2014-12-01), pages 4697 - 4705, XP055744078
URSZULA RAZNY, DANUTA FEDAK, BEATA KIEC-WILK, JOANNA GORALSKA, ANNA GRUCA, ANNA ZDZIENICKA, MALGORZATA KIEC-KLIMCZAK, BOGDAN SOLNI: "Carboxylated and undercarboxylated osteocalcin in metabolic complications of human obesity and prediabetes", DIABETES/METABOLISM RESEARCH AND REVIEWS, vol. 33, no. 3, 7 November 2016 (2016-11-07) - March 2017 (2017-03-01), pages e2862, XP055744065
ANISHA A. GUPTE, SABEK OMAIMA M., FRAGA DANIEL, MINZE LAURIE J., NISHIMOTO SATORU K., LIU JOEY Z., AFSHAR SOLMAZ, GABER LILLIAN, L: "Osteocalcin protects against nonalcoholic steatohepatitis in a mouse model of metabolic syndrome", ENDOCRINOLOGY, vol. 155, no. 12, 3 October 2014 (2014-10-03) - December 2014 (2014-12-01), pages 4697 - 4705, XP055744078
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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