PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ISCHEMIA-REPERFUSION INJURY, CONTAINING BILE ACID

WIPO Patent Application WO/2018/080276

A1

The present invention relates to a composition for preventing, treating, or alleviating ischemia-reperfusion injury, containing bile acid. According to the present invention, bile acid increases intranuclear beta-catenin levels, interferes with the opening of a mitochondria permeable transition pore (mPTP), and has excellent effects, in ischemia-reperfusion injury animal models, of alleviating tissue damage and reducing the size of infarcts, thereby being usable in the prevention, treatment, or alleviation of ischemia-reperfusion injury.

GWON HYEON CHEOL (KR)
JANG HYUNG SUK (KR)
KIM KOUNG LI (KR)
KIM JEONG MIN (KR)

PCT/KR2017/012127

May 03, 2018

October 31, 2017

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SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)

A61K31/575; A23L33/10

KR101414810B1	2014-07-18
KR20000065178A	2000-11-06
CN1853639A	2006-11-01

WOO-YONG LEE, SUK-HEE HAN, TAI-SOON CHO, YOUNG-HYO YOO…: "Effect of ursodeoxycholic acid on ischemia/reperfusion injury in isolated rat heart", ARCHIEVES OF PHARMACAL RESEARCH, vol. 22, no. 5, October 1999 (1999-10-01), pages 479 - 484, XP055594890, DOI: 10.1007/BF02979156
ALI AKDEMIR, CAGDAS SAHIN, OYTUN ERBAS…: "Is ursodeoxycholic acid crucial for ischemia/reperfusion-induced ovarian injury in rat ovary?", ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol. 292, no. 2, August 2015 (2015-08-01), pages 445 - 450, XP055594897, DOI: 10.1007/s00404-015-3646-9
See also references of EP 3533450A4

KIM, Soon Woong (KR)

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