Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISORDERS, CONTAINING SPHINGOSINE-1-PHOSPHATE OR MATERIAL INCREASING EXPRESSION OF SPHK2
Document Type and Number:
WIPO Patent Application WO/2017/039096
Kind Code:
A1
Abstract:
The present invention provides: a pharmaceutical composition, a food composition and a cosmetic composition for preventing or treating metabolic disorders, containing any one selected from the group consisting of sphingosine-1-phosphate, a sphingosine-1-phosphate promoter and a material increasing the expression of Sphk2; and a method for screening for a material for preventing or treating metabolic disorders by using the mechanism. The pharmaceutical composition, the food composition and the cosmetic composition of the present invention can be useful as a pharmaceutical composition, a food composition and a cosmetic composition for preventing or treating metabolic disorders, particularly, a fatty liver such as nonalcoholic fatty liver, dyslipidemia such as hyperlipidemia or hypertriglyceridemia, and obesity, and the screening method using the mechanism can be useful as a method for screening for a material for preventing or treating metabolic disorders.
Inventors:
PARK TAE SIK (KR)
SHIM SOON MI (KR)
LEE SU YEON (KR)
MAENG HYO JIN (KR)
SHIM SOON MI (KR)
LEE SU YEON (KR)
MAENG HYO JIN (KR)
Application Number:
PCT/KR2016/002410
Publication Date:
March 09, 2017
Filing Date:
March 10, 2016
Export Citation:
Assignee:
GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
A61K31/133; A61K8/68; A61K31/661; A61K48/00; A61Q19/00; G01N33/50
Foreign References:
| KR20120058047A | 2012-06-07 | |||
| KR20010008569A | 2001-02-05 |
Other References:
NAGAHASHI, MASAYUKI ET AL.: "Conjugated Bile Acid-activated SIP Receptor 2 is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression", HEPATOLOGY, vol. 61, no. 4, 9 March 2015 (2015-03-09), pages 1216 - 1226
LEE, SU - YEON ET AL.: "Activation of Sphingosine Kinase 2 by Endoplasmic Reticulum Stress Ameliorates Hepatic Steatosis and Insulin Resistance in Mice", HEPATOLOGY, vol. 62, no. 1, July 2015 (2015-07-01), pages 135 - 146
KWONG, ERIC ET AL.: "Bile Acids and Sphingosine-1-phosphate Receptor 2 in Hepatic Lipid Metabolism", ACTA PHARMACEUTICA SINICA B, vol. 5, no. 2, March 2015 (2015-03-01), pages 151 - 157, XP055370182
HASHIMOTO, TAKESHI ET AL.: "Sphingosine Kinase is Induced in Mouse 3T3-L1 Cells and Promotes Adipogenesis", JOURNAL OF LIPID RESEARCH, vol. 50, no. 4, 2009, pages 602 - 610, XP055370184
LEE, SU - YEON ET AL.: "Activation of Sphingosine Kinase 2 by Endoplasmic Reticulum Stress Ameliorates Hepatic Steatosis and Insulin Resistance in Mice", HEPATOLOGY, vol. 62, no. 1, July 2015 (2015-07-01), pages 135 - 146
KWONG, ERIC ET AL.: "Bile Acids and Sphingosine-1-phosphate Receptor 2 in Hepatic Lipid Metabolism", ACTA PHARMACEUTICA SINICA B, vol. 5, no. 2, March 2015 (2015-03-01), pages 151 - 157, XP055370182
HASHIMOTO, TAKESHI ET AL.: "Sphingosine Kinase is Induced in Mouse 3T3-L1 Cells and Promotes Adipogenesis", JOURNAL OF LIPID RESEARCH, vol. 50, no. 4, 2009, pages 602 - 610, XP055370184
Attorney, Agent or Firm:
KIM, Jung Su (KR)
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