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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MUSCULAR WEAKNESS-RELATED DISEASES, CONTAINING BUTYLPYRIDINIUM OR DERIVATIVE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/190643
Kind Code:
A1
Abstract:
The present invention relates to a composition for promoting the differentiation of myoblasts, the composition containing butylpyridinium, a derivative thereof, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition for preventing or treating muscular weakness-related diseases; a food composition for preventing or alleviating muscular weakness-related diseases; a composition for strengthening muscular strength; and a feed or feed composition for strengthening muscular strength. Furthermore, the present invention relates to a method for promoting the differentiation of myoblasts using butylpyridinium, a derivative thereof, or a pharmaceutically acceptable salt thereof; a method for manufacturing differentiated myoblasts; and a method for treating muscular weakness-related diseases.

Inventors:
KWON, Ki Sun (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
PARK, Sung Sup (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
CHUNG, Sun Gun (Department of Physical Medicine and Rehabilitation, Seoul National University Hospital 101, Daehak-ro,,Jongno-gu, Seoul 110-744, 110-744, KR)
LEE, Kwang Pyo (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
LEE, Seung Min (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
CHOI, Jung Yi (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
Application Number:
KR2014/006416
Publication Date:
December 17, 2015
Filing Date:
July 16, 2014
Export Citation:
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Assignee:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, 305-806, KR)
SNU R&DB FOUNDATION (1 Gwanak-ro, Gwanak-gu, Seoul 151-010, 151-010, KR)
International Classes:
A61K31/4425; A61K31/435; A61P21/00
Domestic Patent References:
WO2013177176A12013-11-28
Foreign References:
JP2006517565A2006-07-27
KR20140042759A2014-04-07
KR20130117017A2013-10-25
Other References:
OSSES, NELSON ET AL.: "Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism", BMC CELL BIOLOGY, vol. 10, no. 73, 2009, pages 1 - 17, XP021062018
See also references of EP 3156055A4
Attorney, Agent or Firm:
SON, Min (Hanol Intellectual Property & Law, STX R&D Center 6th Floor, 163, YangJaeCheon-ro,,Gangnam-gu, Seoul 135, 135, KR)
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