Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OBESITY OR SARCOPENIA, CONTAINING IF1 AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2020/055186
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating obesity or sarcopenia, containing ATPase inhibitory factor 1 (IF1) and, more specifically, to a pharmaceutical composition and a food for preventing or treating obesity or sarcopenia, containing, as an active ingredient, IF1 having an effect of suppressed appetite or effects increased muscle mass and muscle production. According to the present invention, ATPase inhibitory factor 1 (IF1) exhibits, in an obesity-induced mouse model, effects of inhibited weight gain and decreased dietary intake without side effects, and exhibits, in obesity-induced or aged mouse, effects of increased muscle mass, increased muscle protein and muscle production, and thus is very useful as an agent for preventing, alleviating or treating metabolic diseases such as obesity, an agent for suppressing appetite and an agent for preventing, alleviating or treating muscle loss-related diseases such as sarcopenia.
Inventors:
SHIN MIN-JEONG (KR)
KIM HYEON SOO (KR)
CHUNG JI HYUNG (KR)
KIM HYEON SOO (KR)
CHUNG JI HYUNG (KR)
Application Number:
PCT/KR2019/011865
Publication Date:
March 19, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K38/17; A23L33/17; A61K38/43; A61P3/04; A61P21/00
Foreign References:
| US20040072739A1 | 2004-04-15 | |||
| US20150065556A1 | 2015-03-05 |
Other References:
FORMENTINI, L.: "Mitochondrial H+-ATP synthase in human skeletal muscle: contribution to dyslipidaemia and insulin resistance", DIABETOLOGIA, 2017, pages 2052 - 2065, XP036614424, DOI: 10.1007/s00125-017-4379-z
KAHANCOVA, A.: "Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1", FEBS LETTERS, 21 February 2018 (2018-02-21), pages 999 - 1009, XP055695008
GENOUX, A.: "Mitochondrial Inhibitory Factor 1 (IF1) Is Present in Human Serum and Is Positively Correlated with HDL-Cholesterol", PLOS ONE, 2011, pages e23949 1 - 8, XP055561582
KAHANCOVA, A.: "Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1", FEBS LETTERS, 21 February 2018 (2018-02-21), pages 999 - 1009, XP055695008
GENOUX, A.: "Mitochondrial Inhibitory Factor 1 (IF1) Is Present in Human Serum and Is Positively Correlated with HDL-Cholesterol", PLOS ONE, 2011, pages e23949 1 - 8, XP055561582
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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