Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2019/004794
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating osteoarthritis comprising a cell or a cell group having a specific size or less, a kit for preparing a cellular therapeutic agent, and a method for preparing a therapeutic agent for osteoarthritis. Mixed cells, which are selected to be equal to or less than a specific size as an effective ingredient of the present invention, of mammalian cells transformed with TGF-β and untransformed mammalian cells minimize aggregation between chondrocytes and have a beneficial therapeutic effect. In addition, when the mixed cells of the selected specific size or less are administered to a patient, patient compliance may be improved, and it is easy to manage quality in a therapeutic agent production facility or a hospital.
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Inventors:
NOH SANG EUN (KR)
LEE SOON DONG (KR)
LEE HYEON YOUL (KR)
HWANG SEUNG TAEH (KR)
KIM HA EUN (KR)
CHOI MIN HO (KR)
LEE SOON DONG (KR)
LEE HYEON YOUL (KR)
HWANG SEUNG TAEH (KR)
KIM HA EUN (KR)
CHOI MIN HO (KR)
Application Number:
PCT/KR2018/007437
Publication Date:
January 03, 2019
Filing Date:
June 29, 2018
Export Citation:
Assignee:
KOLON LIFE SCIENCE INC (KR)
KOLON TISSUEGENE INC (US)
KOLON TISSUEGENE INC (US)
International Classes:
A61K35/32
Foreign References:
| KR100866101B1 | 2008-10-30 | |||
| KR20170073614A | 2017-06-28 | |||
| KR20050002898A | 2005-01-10 | |||
| JP2000500641A | 2000-01-25 | |||
| KR101649375B1 | 2016-08-30 | |||
| KR20150014369A | 2015-02-06 | |||
| US20050152882A1 | 2005-07-14 | |||
| US20160038544A1 | 2016-02-11 | |||
| US7005127B2 | 2006-02-28 | |||
| US7282200B2 | 2007-10-16 |
Other References:
HA, CHUL-WON ET AL.: "Initial phase 1 safety of retrovirally transduced human chondrocytes expressing transforming growth factor-beta-1 in degenerative arthritis patients", CYTOTHERAPY, vol. 14, no. 2, February 2012 (2012-02-01), pages 247 - 256, XP055663878, DOI: 10.3109/14653249.2011.629645
LEE KH ET AL., HUM GENE THER, vol. 12, 2001, pages 1805 - 1813
SUN U. SONG ET AL., TISSUE ENGINEERING, vol. 11, 2005, pages 1516 - 1526
"Remington's Pharmaceutical Sciences", 1995
CYTOTHERAPY, vol. 14, no. 2, February 2012 (2012-02-01), pages 247 - 256
CHAPLAN SR ET AL.: "Quantitative assessment of tactile allodynia in the rat paw", JOURNAL OF NEUROSCIENCE METHODS, vol. 53, 1994, pages 55 - 63, XP024352718, DOI: 10.1016/0165-0270(94)90144-9
DIXON W.J.: "Efficient analysis of experimental observations", ANNUAL REVIEWS PHARMACOLOGY TOXICOLOGY, vol. 20, 1980, pages 441 - 62
See also references of EP 3646878A4
LEE KH ET AL., HUM GENE THER, vol. 12, 2001, pages 1805 - 1813
SUN U. SONG ET AL., TISSUE ENGINEERING, vol. 11, 2005, pages 1516 - 1526
"Remington's Pharmaceutical Sciences", 1995
CYTOTHERAPY, vol. 14, no. 2, February 2012 (2012-02-01), pages 247 - 256
CHAPLAN SR ET AL.: "Quantitative assessment of tactile allodynia in the rat paw", JOURNAL OF NEUROSCIENCE METHODS, vol. 53, 1994, pages 55 - 63, XP024352718, DOI: 10.1016/0165-0270(94)90144-9
DIXON W.J.: "Efficient analysis of experimental observations", ANNUAL REVIEWS PHARMACOLOGY TOXICOLOGY, vol. 20, 1980, pages 441 - 62
See also references of EP 3646878A4
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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