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Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING PARKINSON'S DISEASE, CONTAINING N-TERMINAL TRUNCATED UBIQUITIN C-TERMINAL HYDROLASE-L1 (NT-UCH-L1) AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2013/191509
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing and treating Parkinson's disease, containing N-terminal truncated ubiquitin C-terminal hydrolase-L1 (NT-UCH-L1) as an active ingredient. Specifically, it is ascertained that NT-UCH-L1 in which 11 amino acids are removed from the N-terminal of UCH-L1 is placed in mitochondria, thereby playing an important role in the regulation of stress inducing active oxygen species and mitochondrial damage, and thus NT-UCH-L1 can be used as an active ingredient of a composition for preventing and treating Parkinson's disease.

Inventors:
LEE KONG-JOO (KR)
KIM HYUN JUNG (KR)
KIM HEE-JUNG (KR)
JEONG JAE EUN (KR)
Application Number:
PCT/KR2013/005509
Publication Date:
December 27, 2013
Filing Date:
June 21, 2013
Export Citation:
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Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61K38/46; A61K38/43; A61P25/00; A61P25/16
Foreign References:
KR20070054952A2007-05-30
US7745127B22010-06-29
Other References:
KIM, YU HWA: "Functional Characterization of Ubiquitin C-terminal Hydrolase-Ll in NCI-H157 cells.", THESIS FOR MASTER'S DEGREE, 2009, EWHA WOMANS UNIVERSITY - THE GRADUATE SCHOOL
CHOI, J. ET AL.: "Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases.", J. BIOL. CHEM., vol. 279, no. 13, 13 January 2004 (2004-01-13), pages 13256 - 13264
MERAY, R. K. ET AL.: "Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1.", J. BIOL. CHEM., vol. 282, no. 14, 26 January 2007 (2007-01-26), pages 10567 - 10575
LIM, K. L. ET AL.: "The cast of molecular characters in Parkinson's disease: felons, conspirators, and suspects.", ANN. N. Y. ACAD. SCI., vol. 991, June 2003 (2003-06-01), pages 80 - 92
Attorney, Agent or Firm:
LEE, Won-Hee (642-16 Yoksam-dong, Kangnam-ku, Seoul 135-080, KR)
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