Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PRURITUS, CONTAINING PYRAZOLE DERIVATIVE AS ACTIVE INGREDIENT, AND SCREENING METHOD FOR DETECTING SAME
Document Type and Number:
WIPO Patent Application WO/2018/164442
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating pruritus, containing a pyrazole derivative as an active ingredient, and a screening method for detecting the same. A pharmaceutical composition for preventing or treating pruritus, according to the present invention, can relieve the symptoms of pruritus by inhibiting the activity of intracellular Mrgpr X1, and can relieve the symptoms of pruritus by inhibiting the activity of intracellular hH1R, thereby being usable also as a medicine for preventing or treating histamine-mediated pruritus. In addition, it is has been confirmed through dry skin mouse model experimentation that the composition also has significant alleviation effects on dry skin, thereby being usable as a medicine for treating dry skin. Furthermore, the pharmaceutical composition according to the present invention can relieve the symptoms of pruritus caused by psoriasis, thereby being usable also as a medicine for treating psoriasis. Moreover, the pharmaceutical composition according to the present invention can maintain stable activity, even during in vivo drug administration, without causing adverse reactions.
Inventors:
OH UHTAEK (KR)
LEE JI YEONG (KR)
AN SUNG AE (KR)
LEE JI YEONG (KR)
AN SUNG AE (KR)
Application Number:
PCT/KR2018/002626
Publication Date:
September 13, 2018
Filing Date:
March 06, 2018
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
KANZEN CO LTD (KR)
KANZEN CO LTD (KR)
International Classes:
A61K31/415; A23L33/10; G01N33/50; G01N33/68
Domestic Patent References:
| WO2014069554A1 | 2014-05-08 | |||
| WO1998041519A1 | 1998-09-24 |
Foreign References:
| JPH0673014A | 1994-03-15 |
Other References:
BANDELL, M.: "Itching for Insight", CELL, vol. 139, 24 December 2009 (2009-12-24), pages 1224 - 1225, XP055630660
OHSAWA, Y.: "The Role of Histamine HI and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study", ALLERGOLOGY INTERNATIONAL, vol. 63, 2014, pages 533 - 542, XP055606370
CELL, vol. 139, 2009, pages 1353 - 1365
JPN J PHARMACOL, vol. 88, no. 3, March 2002 (2002-03-01), pages 285 - 92
See also references of EP 3593799A4
OHSAWA, Y.: "The Role of Histamine HI and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study", ALLERGOLOGY INTERNATIONAL, vol. 63, 2014, pages 533 - 542, XP055606370
CELL, vol. 139, 2009, pages 1353 - 1365
JPN J PHARMACOL, vol. 88, no. 3, March 2002 (2002-03-01), pages 285 - 92
See also references of EP 3593799A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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