Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING TYPE 2 DIABETES, CONTAINING QUERCETIN-3-O-XYLOSIDE
Document Type and Number:
WIPO Patent Application WO/2021/071334
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing and treating diabetes, containing quercetin-3-O-xyloside as an active ingredient. More specifically, the present invention demonstrates that: quercetin-3-O-xyloside reduces insulin resistance in insulin resistance induced myocytes, promotes glucose uptake and promotes the expression of GLUT-4, which is a glucose transporter membrane protein, and increases the rate of glucose uptake, thereby having antidiabetic effects; quercetin-3-O-xyloside inhibits α-glucosidase at least twice as effectively as acarbose, which is a current therapeutic agent for type 2 diabetes, thereby having excellent antidiabetic effects on type 2 diabetes; and, compared to a single substance of quercetin-3-O-xyloside, a 1:1 (mole : mole) complex of quercetin-3-O-xyloside and quercetin-3-O-rhamnoside has the synergistic effect of further increasing the rate of glucose uptake, thereby increasing antidiabetic effects. In addition, the present invention relates to a pharmaceutical composition for preventing and treating diabetes, containing the substance.
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Inventors:
PARK YONG IL (KR)
PARK GI EUN (KR)
SOHNG JAE KYUNG (KR)
RAMAKANTA LAMMICHHANE (KR)
PARK GI EUN (KR)
SOHNG JAE KYUNG (KR)
RAMAKANTA LAMMICHHANE (KR)
Application Number:
PCT/KR2020/013854
Publication Date:
April 15, 2021
Filing Date:
October 12, 2020
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K31/7048; A23L33/125; A61P3/10
Foreign References:
| KR20170043363A | 2017-04-21 | |||
| KR20100092786A | 2010-08-23 | |||
| KR20090091615A | 2009-08-28 |
Other References:
DAI XIAOQIAN, DING YE, ZHANG ZHAOFENG, CAI XIAXIA, LI YONG: "Quercetin and quercitrin protect against cytokine-induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 31, no. 1, 1 January 2013 (2013-01-01), GR, pages 265 - 271, XP055799821, ISSN: 1107-3756, DOI: 10.3892/ijmm.2012.1177
LEE JISUN; CHOI JI WON; SOHNG JAE KYUNG; PANDEY RAMESH PRASAD; PARK YONG IL: "The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway", INTERNATIONAL HNMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 31, 17 December 2015 (2015-12-17), NL, pages 88 - 97, XP029413017, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.12.008
SEO JEONG YEON, PANDEY RAMESH PRASAD, LEE JISUN, SOHNG JAE KYUNG, NAMKUNG WAN, PARK YONG IL: "Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosis", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 55, 1 March 2019 (2019-03-01), AMSTERDAM, NL, pages 40 - 49, XP055799827, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2018.07.011
KATHRYN L LIPSON, SONYA G FONSECA, FUMIHIKO URANO: "Endoplasmic Reticulum Stress-Induced Apoptosis and Autoimmunity in Diabetes.", CURRENT MOLECULAR MEDICINE., vol. 6, no. 1, 2006, pages 71 - 77, XP009527260, DOI: 10.2174/156652406775574613
LEE JISUN; CHOI JI WON; SOHNG JAE KYUNG; PANDEY RAMESH PRASAD; PARK YONG IL: "The immunostimulating activity of quercetin 3-O-xyloside in murine macrophages via activation of the ASK1/MAPK/NF-κB signaling pathway", INTERNATIONAL HNMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 31, 17 December 2015 (2015-12-17), NL, pages 88 - 97, XP029413017, ISSN: 1567-5769, DOI: 10.1016/j.intimp.2015.12.008
SEO JEONG YEON, PANDEY RAMESH PRASAD, LEE JISUN, SOHNG JAE KYUNG, NAMKUNG WAN, PARK YONG IL: "Quercetin 3-O-xyloside ameliorates acute pancreatitis in vitro via the reduction of ER stress and enhancement of apoptosis", PHYTOMEDICINE, ELSEVIER, AMSTERDAM, NL, vol. 55, 1 March 2019 (2019-03-01), AMSTERDAM, NL, pages 40 - 49, XP055799827, ISSN: 0944-7113, DOI: 10.1016/j.phymed.2018.07.011
KATHRYN L LIPSON, SONYA G FONSECA, FUMIHIKO URANO: "Endoplasmic Reticulum Stress-Induced Apoptosis and Autoimmunity in Diabetes.", CURRENT MOLECULAR MEDICINE., vol. 6, no. 1, 2006, pages 71 - 77, XP009527260, DOI: 10.2174/156652406775574613
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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