Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING VASCULAR DISORDERS INCLUDING MESENCHYMAL STEM CELL EXPRESSING HEPATOCYTE GROWTH FACTOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2019/027299
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating vascular disorders including a mesenchymal stem cell expressing a hepatocyte growth factor (HGF) protein as an active ingredient. This pharmaceutical composition for preventing or treating vascular disorders including a mesenchymal stem cell expressing an HGF protein as an active ingredient expresses HGF to induce vascularization, thereby stimulating the formation of capillaries and enhancing cardiac function. Therefore, the pharmaceutical composition according to the present invention can be usefully applied as pharmaceutical composition for preventing or treating vascular disorders, in particular, cardiovascular disorders.
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Inventors:
PARK HUN-JUN (KR)
PARK BONG-WOO (KR)
JUNG SOO-HYUN (KR)
LEE SOON MIN (KR)
KIM HEY-YON (KR)
CHO DONG-WOO (KR)
JANG JINAH (KR)
KIM SEOK-WON (KR)
DAS SANSKRITA (KR)
PARK BONG-WOO (KR)
JUNG SOO-HYUN (KR)
LEE SOON MIN (KR)
KIM HEY-YON (KR)
CHO DONG-WOO (KR)
JANG JINAH (KR)
KIM SEOK-WON (KR)
DAS SANSKRITA (KR)
Application Number:
PCT/KR2018/008903
Publication Date:
April 25, 2019
Filing Date:
August 06, 2018
Export Citation:
Assignee:
SLBIGEN INC (KR)
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
POSTECH ACAD IND FOUND (KR)
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
POSTECH ACAD IND FOUND (KR)
International Classes:
A61K35/28; C07K14/475; C12N5/0775; C12N15/86
Foreign References:
| KR20150009528A | 2015-01-26 | |||
| US5547856A | 1996-08-20 | |||
| KR20010033064A | 2001-04-25 | |||
| KR20170093084A | 2017-08-14 |
Other References:
ZHU, XIAOYU ET AL.: "Establishment of a Lentiviral Vector Encoding Human HGF and the Infection of Human ADSCs", BIOMED RESEARCH INTERNATIONAL, vol. 2013, 2013, pages 1 - 8, XP055594990
WANG, QIANG-LI ET AL.: "Mesenchymal Stem Cell -loaded Cardiac Patch Promotes Epicardial Activation and Repair of the Infarcted Myocardium", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 21, no. 9, 28 February 2017 (2017-02-28), pages 1751 - 1766, XP055594993
WANG, QIANG-LI ET AL.: "Mesenchymal Stem Cell -loaded Cardiac Patch Promotes Epicardial Activation and Repair of the Infarcted Myocardium", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 21, no. 9, 28 February 2017 (2017-02-28), pages 1751 - 1766, XP055594993
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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